PMID- 17597296
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20181113
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 422
IP  - 1
DP  - 2007 Jul 5
TI  - Olfactory system modulation of hippocampal cell death.
PG  - 13-7
AB  - The hippocampal dentate gyrus is a major recipient of olfactory input in rodents, 
      via connections from the olfactory (piriform) cortex and the olfactory bulb to 
      the entorhinal cortex. Given this connectivity and the known role of activity in 
      dentate gyrus granule cell survival, the present experiment examined the 
      immediate effects of loss of olfactory input to the hippocampus on apoptosis. 
      Adults rats underwent unilateral or bilateral olfactory bulb ablations (OBX), and 
      allowed to recover 24-72 h before the piriform cortex and hippocampal dentate 
      gyrus were processed for terminal deoxynucleotidyl transferase-mediated dUTP nick 
      end labeling [TUNEL] of apoptotic cells. OBX transiently increased TUNEL-positive 
      cells in the ipsilateral piriform cortex and dentate gyrus. Increased 
      TUNEL-labeling was apparent within 24h in both structures, but was more extensive 
      and prolonged in piriform cortex. The results suggest a trans-synaptic regulation 
      of cell survival through at least two synapses.
FAU - Pope, Kenneth
AU  - Pope K
AD  - Department of Zoology, University of Oklahoma, Norman, OK 73019, USA.
FAU - Wilson, Donald A
AU  - Wilson DA
LA  - eng
GR  - R01 DC003906/DC/NIDCD NIH HHS/United States
GR  - R01 DC003906-11/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070614
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Cell Count
MH  - Cell Death/physiology
MH  - Cell Nucleus/drug effects/physiology/ultrastructure
MH  - Cerebral Cortex/cytology/physiology
MH  - Dentate Gyrus/cytology/physiology
MH  - Hippocampus/cytology/*physiology
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Olfactory Bulb/cytology/physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Smell/*physiology
PMC - PMC2713745
MID - NIHMS28309
EDAT- 2007/06/29 09:00
MHDA- 2007/09/27 09:00
PMCR- 2009/07/21
CRDT- 2007/06/29 09:00
PHST- 2007/04/04 00:00 [received]
PHST- 2007/04/30 00:00 [revised]
PHST- 2007/05/04 00:00 [accepted]
PHST- 2007/06/29 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/06/29 09:00 [entrez]
PHST- 2009/07/21 00:00 [pmc-release]
AID - S0304-3940(07)00559-9 [pii]
AID - 10.1016/j.neulet.2007.05.041 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Jul 5;422(1):13-7. doi: 10.1016/j.neulet.2007.05.041. Epub 
      2007 Jun 14.