PMID- 17597627
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20081121
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 117
IP  - 9
DP  - 2007 Sep
TI  - Vaccinations with dendritic cells primed with apoptotic tumor cells can elicit 
      preventive antitumor immunity in a poorly immunogenic animal model of squamous 
      cell carcinoma.
PG  - 1588-93
AB  - BACKGROUND: Dendritic cells (DCs) can effectively mediate the prevention and 
      regression of a variety of solid tumors. However, not much has been determined 
      about their efficacy for the prevention of squamous cell carcinoma (SCC), partly 
      because there are no known tumor-specific antigens or low immunogenicity for this 
      tumor. The authors aimed to determine the preventive effect of DC-based 
      immunotherapy in a SCC animal model. METHODS: Bone marrow derived DCs of C3H/He 
      mice were pulsed with ultraviolet-B-irradiated apoptotic SCCVII cells, which are 
      known as a poorly immunogenic SCC cell line. After the animals were vaccinated 
      with these DCs, a tumorigenic dosage of SCCVII cells was subcutaneously injected 
      and the tumor growth assessed. RESULTS: Animals pretreated with apoptotic SCCVII 
      cell-pulsed DCs showed tumor extinction within 2 weeks after forming a small 
      tumor, or there was no tumor formation at all, as seen in 81% of the mice; in the 
      remaining 19% of the mice, tumor growth was significantly retarded compared with 
      the control groups (P=.0029). The SCCVII cell-specific T-cell response was 
      observed in the immunized mice. CONCLUSION: The adoptive transfer of DCs primed 
      with apoptotic tumor cells can hopefully serve as an effective preventive 
      vaccine, even in poorly immunogenic SCC.
FAU - Jeong, Han-Sin
AU  - Jeong HS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Cancer Center, Samsung 
      Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Hyunah
AU  - Lee H
FAU - Ko, Yejeung
AU  - Ko Y
FAU - Son, Young-Ik
AU  - Son YI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Cancer Vaccines)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Cancer Vaccines/*immunology
MH  - Carcinoma, Squamous Cell/immunology/pathology/*prevention & control
MH  - Cell Line, Tumor
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/metabolism
MH  - Disease Models, Animal
MH  - Immunity
MH  - *Immunotherapy, Adoptive
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/biosynthesis
MH  - Mice
MH  - Mice, Inbred C3H
MH  - T-Lymphocytes/*immunology
EDAT- 2007/06/29 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/06/29 09:00
PHST- 2007/06/29 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/06/29 09:00 [entrez]
AID - 10.1097/MLG.0b013e31806dd073 [doi]
PST - ppublish
SO  - Laryngoscope. 2007 Sep;117(9):1588-93. doi: 10.1097/MLG.0b013e31806dd073.