PMID- 1759851
OWN - NLM
STAT- MEDLINE
DCOM- 19920131
LR  - 20190902
IS  - 0090-4341 (Print)
IS  - 0090-4341 (Linking)
VI  - 21
IP  - 4
DP  - 1991 Nov
TI  - Toxicity of oleic acid anilide in rats.
PG  - 571-7
AB  - In the present investigation, we have studied the toxic potential of oleic acid 
      anilide (OAA) and heated oleic acid anilide (HOAA) in relation to the toxic oil 
      syndrome (TOS). Male Sprague-Dawley rats were given 250 mg/kg of OAA or HOAA in 
      mineral oil by gavage, on alternate days for 2 weeks (total 7 doses). The control 
      rats received an equal volume of mineral oil only. The animals were sacrificed at 
      days 1, 7, and 28 following the last dose. Ratio of organ-to-body weight showed 
      increases in spleen and kidney of HOAA and OAA treated rats, respectively, at day 
      1 while this ratio for liver in HOAA treated group showed a decrease at day 1. 
      Among blood parameters, white blood cells increased in HOAA treated group at day 
      1 and in both OAA and HOAA groups at day 28. Mean corpuscular hemoglobin (MCH) 
      and mean cell volume (MCV) also showed increases in the HOAA treated rats at days 
      7 and 28. Serum lactate dehydrogenase (LDH) decreased in both OAA and HOAA 
      treated rats at day 1, while at day 7 the decrease was confined only to the HOAA 
      group. Serum glutamic oxalacetic transaminase (GOT) and glutamic pyruvic 
      transaminase (GPT) activities also decreased at most of the time points. Liver 
      mitochondrial ATPase activity decreased in the HOAA group at day 7 and in the OAA 
      group at day 28. Among serum immunoglobulins, IgA levels increased throughout the 
      study but the changes were more pronounced in HOAA treated rats.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Khan, M F
AU  - Khan MF
AD  - Department of Pathology, University of Texas Medical Branch, Galveston 77550.
FAU - Kaphalia, B S
AU  - Kaphalia BS
FAU - Palafox, A
AU  - Palafox A
FAU - Jerrells, T R
AU  - Jerrells TR
FAU - Ansari, G A
AU  - Ansari GA
LA  - eng
GR  - ES 04815/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Environ Contam Toxicol
JT  - Archives of environmental contamination and toxicology
JID - 0357245
RN  - 0 (Anilides)
RN  - 0 (Oleic Acids)
RN  - 5429-85-6 (oleoylanilide)
SB  - IM
MH  - Anilides/*toxicity
MH  - Animals
MH  - Body Weight/drug effects
MH  - Hot Temperature
MH  - Immune System/drug effects
MH  - Male
MH  - Oleic Acids/*toxicity
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 10.1007/BF01183880 [doi]
PST - ppublish
SO  - Arch Environ Contam Toxicol. 1991 Nov;21(4):571-7. doi: 10.1007/BF01183880.