PMID- 17598867
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20131121
IS  - 0905-4383 (Print)
IS  - 0905-4383 (Linking)
VI  - 23
IP  - 4
DP  - 2007 Aug
TI  - Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in 
      NC/Nga mice.
PG  - 135-44
AB  - BACKGROUND: Atopic dermatitis (AD) is a common pruritic inflammatory skin 
      disease, which occurs primarily in childhood. Recently, narrow-band ultraviolet B 
      (UVB) phototherapy has been used to treat AD, but the mechanism involved is 
      unknown. In this study, we investigated whether UVB irradiation influences AD in 
      the NC/Nga mouse. METHODS: The mice were separated into three groups: control, 
      AD-control (immunized with mite antigens), and AD+UVB-irradiated (immunized with 
      mite antigens and UVB irradiation) groups. The mice in the irradiation group were 
      exposed to 1 kJ/m(2)/day twice a week from 6 to 12 weeks of age. Animals in the 
      control and AD-control groups were shaved, but not irradiated. RESULTS: In the 
      AD+UVB-irradiated group, the atopy score, ear thickness, and total immunoglobulin 
      E (IgE) were increased in comparison with the AD-control group. On day 40, the 
      levels of interleukin (IL)-4, IL-5, and IL-10 in the spleen lymphocytes were 
      significantly increased compared with the AD-control group, resulting in a marked 
      decrease of the interferon (IFN)-gamma/IL-4 ratio compared with the AD-control 
      group. In addition, the levels of IL-6, tumor necrosis factor (TNF)-alpha, and 
      NO(x) production by peritoneal macrophages were significantly elevated. 
      CONCLUSION: These results indicate that UVB irradiation promotes the development 
      of AD-like skin lesions in NC/Nga mice.
FAU - Mutou, Yasuko
AU  - Mutou Y
AD  - Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo 
      University of Science, Chiba, Japan. j3105709@ed.noda.tus.ac.jp
FAU - Ibuki, Yuko
AU  - Ibuki Y
FAU - Kojima, Shuji
AU  - Kojima S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Photodermatol Photoimmunol Photomed
JT  - Photodermatology, photoimmunology & photomedicine
JID - 9013641
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Cells, Cultured
MH  - Dermatitis, Atopic/blood/*immunology/metabolism
MH  - Disease Models, Animal
MH  - Ear/pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Genetic Predisposition to Disease
MH  - Immunoglobulin E/*blood
MH  - Interferon-gamma/*metabolism
MH  - Interleukins/*biosynthesis
MH  - Lymphocytes/metabolism
MH  - Macrophages/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nitric Oxide/*biosynthesis
MH  - Peritoneum/cytology
MH  - Spleen/cytology
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Ultraviolet Rays/*adverse effects
EDAT- 2007/06/30 09:00
MHDA- 2007/09/28 09:00
CRDT- 2007/06/30 09:00
PHST- 2007/06/30 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/06/30 09:00 [entrez]
AID - PPP297 [pii]
AID - 10.1111/j.1600-0781.2007.00297.x [doi]
PST - ppublish
SO  - Photodermatol Photoimmunol Photomed. 2007 Aug;23(4):135-44. doi: 
      10.1111/j.1600-0781.2007.00297.x.