PMID- 17599854
OWN - NLM
STAT- MEDLINE
DCOM- 20070719
LR  - 20210204
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 13
IP  - 3
DP  - 2007 May-Jun
TI  - Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by 
      administration of caffeine in coffee.
PG  - 239-43
AB  - OBJECTIVE: To test whether caffeine administered in coffee increases postprandial 
      hyperglycemia in patients with type 2 diabetes who are habitual coffee drinkers. 
      METHODS: The study used a within-subject, double-blind, placebo-controlled 
      experimental design. Twenty adult coffee drinkers (11 women and 9 men) with type 
      2 diabetes treated with diet, exercise, orally administered antidiabetic agents, 
      or some combination of these factors completed two mixed-meal tolerance tests 
      (MMTT) after an overnight fast. Before the MMTT, each study participant received 
      250 mg of caffeine in 16 oz (475 mL) of decaffeinated coffee or decaffeinated 
      coffee alone, with the treatment order counterbalanced in the group. Fasting and 
      1-hour and 2-hour postprandial blood samples were collected for measurement of 
      plasma glucose and insulin concentrations. RESULTS: Glucose and insulin responses 
      to the MMTT were quantified by the incremental areas under the 2-hour 
      concentration-time curves (AUC2h). Administration of caffeine in decaffeinated 
      coffee increased postprandial glucose and insulin responses (both P = 0.02). The 
      mean plasma glucose AUC2h was 28% larger and the mean plasma insulin AUC2h was 
      19% larger after administration of caffeine than after administration of placebo. 
      CONCLUSION: Other constituents in coffee did not prevent the exaggeration of 
      postprandial hyperglycemia by caffeine in these patients with type 2 diabetes, 
      who were habitual coffee drinkers. Repeated on a daily basis, such effects could 
      impair long-term glucose control in those patients with type 2 diabetes who 
      habitually drink coffee or other caffeinated beverages.
FAU - Lane, James D
AU  - Lane JD
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 
      Durham, North Carolina 27710, USA.
FAU - Hwang, Allen L
AU  - Hwang AL
FAU - Feinglos, Mark N
AU  - Feinglos MN
FAU - Surwit, Richard S
AU  - Surwit RS
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Blood Glucose)
RN  - 0 (Coffee)
RN  - 0 (Insulin)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Caffeine/*adverse effects
MH  - Coffee/*adverse effects
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hyperglycemia/blood/*chemically induced/etiology
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
EDAT- 2007/06/30 09:00
MHDA- 2007/07/20 09:00
CRDT- 2007/06/30 09:00
PHST- 2007/06/30 09:00 [pubmed]
PHST- 2007/07/20 09:00 [medline]
PHST- 2007/06/30 09:00 [entrez]
AID - S1530-891X(20)41830-0 [pii]
AID - 10.4158/EP.13.3.239 [doi]
PST - ppublish
SO  - Endocr Pract. 2007 May-Jun;13(3):239-43. doi: 10.4158/EP.13.3.239.