PMID- 17600774
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20071026
IS  - 1568-7864 (Print)
IS  - 1568-7856 (Linking)
VI  - 6
IP  - 11
DP  - 2007 Nov
TI  - Immunoglobulin gene conversion: synthesizing antibody diversification and DNA 
      repair.
PG  - 1557-71
AB  - Recent developments in the field of antibody (Ab) diversification have rapidly 
      advanced our understanding of the molecular mechanism underlying these events. 
      Key to these developments was the identification of activation-induced cytidine 
      deaminase (AID) as the central regulator of secondary Ab diversification, and the 
      elucidation of its primary function as a DNA deaminase. Incredibly, current 
      literature suggests the existence of a shared pathway, common to all secondary 
      diversification processes, from which the separate outcomes branch outwards at 
      various points. Immunoglobulin gene conversion (IGC) is one of these mechanisms 
      and is used by a number of vertebrate species in both the development of the 
      pre-immune repertoire and in affinity maturation. In a manner similar to other Ab 
      diversification mechanisms, IGC has managed to co-opt a normal DNA repair pathway 
      for the generation of receptor diversity. In the case of IGC specifically, that 
      pathway is homologous recombination (HR). A burgeoning wealth of genetic, 
      biochemical and structural data has clarified the roles of many key HR factors, 
      allowing new insight into its molecular mechanism. These insights, combined with 
      those from the common mechanism of AID action, synergize to develop an emerging 
      picture of the mechanism underlying IGC.
FAU - Tang, Ephraim S
AU  - Tang ES
AD  - Department of Immunology, University of Toronto, Medical Sciences Bldg. 5265, 
      Toronto, Canada M5S 1A8.
FAU - Martin, Alberto
AU  - Martin A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070628
PL  - Netherlands
TA  - DNA Repair (Amst)
JT  - DNA repair
JID - 101139138
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Antibody Diversity/*genetics
MH  - Cell Cycle
MH  - DNA/chemistry/metabolism
MH  - *DNA Repair
MH  - Gene Conversion
MH  - *Gene Rearrangement, B-Lymphocyte
MH  - Humans
MH  - Immunoglobulin Class Switching
MH  - Models, Biological
RF  - 121
EDAT- 2007/06/30 09:00
MHDA- 2008/02/27 09:00
CRDT- 2007/06/30 09:00
PHST- 2007/03/22 00:00 [received]
PHST- 2007/05/15 00:00 [revised]
PHST- 2007/05/15 00:00 [accepted]
PHST- 2007/06/30 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/06/30 09:00 [entrez]
AID - S1568-7864(07)00200-5 [pii]
AID - 10.1016/j.dnarep.2007.05.002 [doi]
PST - ppublish
SO  - DNA Repair (Amst). 2007 Nov;6(11):1557-71. doi: 10.1016/j.dnarep.2007.05.002. 
      Epub 2007 Jun 28.