PMID- 17602813
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20131121
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 45
IP  - 11
DP  - 2007 Nov
TI  - Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes.
PG  - 2138-44
AB  - The mast cell-mediated immediate-type allergic reaction is involved in many 
      allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of 
      mast cells starts the process of degranulation resulting in release of mediators 
      such as histamine and an array of inflammatory cytokines. In this report, we 
      investigated the effect of aqueous extract of Amomum xanthiodes (Zingiberaceae) 
      (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms 
      of action. AXE inhibited compound 48/80-induced systemic reactions and serum 
      histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive 
      cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular 
      calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, 
      AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but 
      not extracellular signal-regulated kinase and c-jun N-terminal kinase, and 
      downstream tumor necrosis factor (TNF)-alpha production in phorbol 12-myristate 
      13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings 
      provide evidence that AXE inhibits mast cell-derived allergic reactions, and that 
      intracellular calcium, TNF-alpha, and p38 MAPK are involved in these effects.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Department of Pharmacology, Kyungpook National University Medical School, Daegu 
      700-422, Republic of Korea. shkim72@knu.ac.kr
FAU - Lee, Soyoung
AU  - Lee S
FAU - Kim, In Kyeom
AU  - Kim IK
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
FAU - Moon, Jin-Young
AU  - Moon JY
FAU - Park, Won-Hwan
AU  - Park WH
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070524
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Phorbol Esters)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 24928-15-2 (phorbol-12,13-diacetate)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Amomum/*chemistry
MH  - Animals
MH  - Anti-Allergic Agents/chemistry/therapeutic use
MH  - Calcimycin
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Histamine
MH  - Hypersensitivity/*drug therapy
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phorbol Esters
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - p-Methoxy-N-methylphenethylamine/adverse effects
MH  - p38 Mitogen-Activated Protein Kinases/genetics/metabolism
EDAT- 2007/07/03 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/07/03 09:00
PHST- 2006/09/22 00:00 [received]
PHST- 2007/04/23 00:00 [revised]
PHST- 2007/05/12 00:00 [accepted]
PHST- 2007/07/03 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/07/03 09:00 [entrez]
AID - S0278-6915(07)00173-1 [pii]
AID - 10.1016/j.fct.2007.05.011 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2007 Nov;45(11):2138-44. doi: 10.1016/j.fct.2007.05.011. Epub 
      2007 May 24.