PMID- 17603050
OWN - NLM
STAT- MEDLINE
DCOM- 20080804
LR  - 20171116
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 89
IP  - 6
DP  - 2008 Jun
TI  - Differing mechanisms of meiotic segregation in spermatozoa from three carriers of 
      a pericentric inversion of chromosome 8.
PG  - 1637-40
AB  - OBJECTIVE: To determine the meiotic segregation of a pericentric inversion of 
      chromosome 8 in three carriers. DESIGN: Analysis of sperm nuclei by fluorescence 
      in situ hybridization (FISH). SETTING: University hospital. PATIENT(S): Three 
      males with an inv(8). INTERVENTION(S): Triple FISH with the 8q and 8p 
      subtelomeres and the specific alphoid of chromosome 9 probes. MAIN OUTCOME 
      MEASURE(S): Meiotic segregation differences between carriers. RESULT(S): The 
      frequencies of nonrecombinant gametes were 97%, 60.94%, and 61.03%. The 
      frequencies of recombinant sperm were 1.44%, 37.71%, and 37.70%, whereas the size 
      of the inverted segment represented 31%, 61%, and 80% of the size of the whole 
      chromosome 8. CONCLUSION(S): Many factors seem to influence the production of 
      recombinant chromosomes: the affected chromosome and involved region, location of 
      the breakpoints, or size of the inverted segment. Our results show that the rate 
      of recombination varies principally according to the size of the inverted 
      segment.
FAU - Caer, Emilie
AU  - Caer E
AD  - Service de Cytogenetique, Cytologie et Biologie de la Reproduction, CHU Morvan, 
      Brest, France.
FAU - Perrin, Aurore
AU  - Perrin A
FAU - Douet-Guilbert, Nathalie
AU  - Douet-Guilbert N
FAU - Amice, Veronique
AU  - Amice V
FAU - De Braekeleer, Marc
AU  - De Braekeleer M
FAU - Morel, Frederic
AU  - Morel F
LA  - eng
PT  - Journal Article
DEP - 20070702
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 8
MH  - Gene Frequency
MH  - *Genetic Carrier Screening
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Meiosis
MH  - Recombination, Genetic
MH  - Sperm Head/ultrastructure
MH  - Spermatozoa/*cytology
EDAT- 2007/07/03 09:00
MHDA- 2008/08/05 09:00
CRDT- 2007/07/03 09:00
PHST- 2006/12/13 00:00 [received]
PHST- 2007/04/30 00:00 [revised]
PHST- 2007/04/30 00:00 [accepted]
PHST- 2007/07/03 09:00 [pubmed]
PHST- 2008/08/05 09:00 [medline]
PHST- 2007/07/03 09:00 [entrez]
AID - S0015-0282(07)01025-4 [pii]
AID - 10.1016/j.fertnstert.2007.04.056 [doi]
PST - ppublish
SO  - Fertil Steril. 2008 Jun;89(6):1637-40. doi: 10.1016/j.fertnstert.2007.04.056. 
      Epub 2007 Jul 2.