PMID- 17603808
OWN - NLM
STAT- MEDLINE
DCOM- 20071031
LR  - 20131121
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 61
IP  - 10
DP  - 2007 Oct
TI  - Differential modulation of a 40 kDa catecholamine regulated protein in the core 
      and shell subcompartments of the nucleus accumbens following chronic quinpirole 
      and haloperidol administration in the rat.
PG  - 835-42
AB  - Past reports have shown dopamine (DA) D2/D3 receptor agonist quinpirole (QNP) and 
      the DA D2 receptor antagonist, haloperidol (HAL) display a significant increase 
      in expression of catecholamine regulated protein (CRP40) in the nucleus accumbens 
      (NAcc) and the striatum, respectively. The present study investigated the in vivo 
      effects of QNP and HAL on CRP40 protein levels within the core and shell 
      subcompartments of the NAcc. As significant homology exists between CRP40 and 
      Hsp70/Hsc70, parallel studies with inducible Hsp70 and constitutive Hsc70 were 
      conducted to establish the specificity with respect to QNP on Hsp70 and CRP40. 
      Results demonstrated that CRP40 protein was significantly expressed in the shell 
      relative to the core region of NAcc following chronic QNP (+16.28%+/-0.42%, 
      P<0.05) and CRP40 protein was significantly expressed in the core vs. the shell 
      following chronic HAL (+36.02%+/-0.75%, P<0.05). There was no significant change 
      in Hsp70 protein levels following chronic QNP or HAL administration. The results 
      demonstrated selective modulation of CRP40 within NAcc by QNP and HAL treatment, 
      without affecting Hsp70.
CI  - Copyright (c) 2007 Wiley-Liss, Inc.
FAU - Gabriele, Joseph
AU  - Gabriele J
AD  - Department of Psychiatry and Behavioral Neuroscience, McMaster University, 
      Hamilton, Ontario, Canada L8N 3Z5.
FAU - Thomas, Nancy
AU  - Thomas N
FAU - N-Marandi, Sevil
AU  - N-Marandi S
FAU - Mishra, Ram
AU  - Mishra R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (catecholamine-regulated protein, 40 kDa)
RN  - 20OP60125T (Quinpirole)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Dopamine Agonists/*administration & dosage
MH  - Dopamine Antagonists/*administration & dosage
MH  - Drug Administration Schedule
MH  - Gene Expression Regulation/drug effects
MH  - HSP70 Heat-Shock Proteins/*metabolism
MH  - Haloperidol/*administration & dosage
MH  - Male
MH  - Nerve Tissue Proteins/*metabolism
MH  - Nucleus Accumbens/anatomy & histology/*drug effects
MH  - Quinpirole/*administration & dosage
MH  - Rats
MH  - Rats, Long-Evans
EDAT- 2007/07/03 09:00
MHDA- 2007/11/01 09:00
CRDT- 2007/07/03 09:00
PHST- 2007/07/03 09:00 [pubmed]
PHST- 2007/11/01 09:00 [medline]
PHST- 2007/07/03 09:00 [entrez]
AID - 10.1002/syn.20435 [doi]
PST - ppublish
SO  - Synapse. 2007 Oct;61(10):835-42. doi: 10.1002/syn.20435.