PMID- 17604122
OWN - NLM
STAT- MEDLINE
DCOM- 20080109
LR  - 20221207
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 153
IP  - 1
DP  - 2007 Sep 30
TI  - A quantitative association study between schizotypal traits and COMT, PRODH and 
      BDNF genes in a healthy Chinese population.
PG  - 7-15
AB  - Previous studies have suggested that catechol-O-methyltransferase (COMT), proline 
      dehydrogenase (PRODH), and brain-derived neurotrophic factor (BDNF) genes are 
      possible susceptibility genes for schizophrenia. We hypothesized that these genes 
      are also associated with schizotypal traits, which are heritable and related to 
      schizophrenia. We genotyped five single nucleotide polymorphism (SNPs) from the 
      COMT, PRODH and BDNF genes, and performed a series of association analyses 
      between alleles, genotypes or haplotypes, and quantitative schizotypal trait 
      scores derived from the Schizotypal Personality Questionnaire (SPQ), in 465 
      Chinese healthy subjects. We found that 'years of education' was a major 
      influence on seven out of nine schizotypal components, three schizotypal factors 
      and the total SPQ scores. Molecular genetic analysis of COMT, PRODH and BDNF 
      genes showed no significant effects of any variants on schizotypal components or 
      factors of SPQ after correction for multiple testing, although there were weak 
      association between COMT Val158Met (rs4680G/A) and the odd speech subscale 
      (allele-wise, P=0.04; genotype-wise, P=0.049), between COMT Val158Met (rs4680G/A) 
      and the suspiciousness subscale (genotype-wise, P=0.024), and between BDNF 
      Val66Met and the Factor 2 interpersonal measure (genotype-wise, P=0.027) before 
      correction. Furthermore, we found SNP Val158Met (rs4680) of the COMT gene 
      significantly influenced the scores of some of schizotypal traits including total 
      SPQ score, the disorganization factor and the constricted affect subscale in male 
      subjects only. However, the effect was in the opposite direction of an earlier 
      association with the SPQ reported by Avramopoulos et al. [Avramopoulos, D., 
      Stefanis, N.C., Hantoumi, I., Smyrnis, N., Evdokimidis, I., Stefanis, C.N., 2002. 
      Higher scores of self reported schizotypy in healthy young males carrying the 
      COMT high activity allele. Molecular Psychiatry 7, 706-711]. We conclude that SNP 
      Val158Met (rs4680) in the COMT gene may be associated with some schizotypal 
      traits in male subjects, but our results are not conclusive.
FAU - Ma, Xiaohong
AU  - Ma X
AD  - Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, PR China.
FAU - Sun, Jinhua
AU  - Sun J
FAU - Yao, Jing
AU  - Yao J
FAU - Wang, Qiang
AU  - Wang Q
FAU - Hu, Xun
AU  - Hu X
FAU - Deng, Wei
AU  - Deng W
FAU - Sun, Xueli
AU  - Sun X
FAU - Liu, Xiehe
AU  - Liu X
FAU - Murray, Robin M
AU  - Murray RM
FAU - Collier, David A
AU  - Collier DA
FAU - Li, Tao
AU  - Li T
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070629
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 1.5.3.- (Proline Oxidase)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affective Symptoms/diagnosis/genetics
MH  - Age Factors
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - China
MH  - Educational Status
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Proline Oxidase/*genetics
MH  - Schizophrenia/diagnosis/genetics
MH  - Schizophrenic Language
MH  - Schizotypal Personality Disorder/diagnosis/*genetics
MH  - Sex Factors
MH  - Statistics as Topic
EDAT- 2007/07/03 09:00
MHDA- 2008/01/10 09:00
CRDT- 2007/07/03 09:00
PHST- 2006/03/14 00:00 [received]
PHST- 2006/12/14 00:00 [revised]
PHST- 2007/02/03 00:00 [accepted]
PHST- 2007/07/03 09:00 [pubmed]
PHST- 2008/01/10 09:00 [medline]
PHST- 2007/07/03 09:00 [entrez]
AID - S0165-1781(07)00033-9 [pii]
AID - 10.1016/j.psychres.2007.02.003 [doi]
PST - ppublish
SO  - Psychiatry Res. 2007 Sep 30;153(1):7-15. doi: 10.1016/j.psychres.2007.02.003. 
      Epub 2007 Jun 29.