PMID- 17605963
OWN - NLM
STAT- MEDLINE
DCOM- 20070802
LR  - 20131213
IS  - 0025-6196 (Print)
IS  - 0025-6196 (Linking)
VI  - 82
IP  - 7
DP  - 2007 Jul
TI  - Brain injury after cardiopulmonary arrest and its assessment with 
      diffusion-weighted magnetic resonance imaging.
PG  - 828-35
AB  - OBJECTIVE: To characterize the frequency and pattern of diffusion-weighted 
      imaging (DWI) abnormalities detected as part of brain magnetic resonance imaging 
      (MRI) and their association with short-term neurologic outcomes in patients 
      successfully resuscitated after cardiopulmonary arrest (CPA). PATIENTS AND 
      METHODS: We retrospectively analyzed a case series of patients who experienced 
      CPA between May 1, 2000, and April 29, 2004, at St Luke's Hospital in 
      Jacksonville, Fla. Eligible patients required treatment by the Code Blue team and 
      had 1 DWI study before discharge or death. Two neuroradiologists jointly 
      classified DWI abnormalities by anatomic location. Outcome was measured by 
      Cerebral Performance Category score. RESULTS: Resuscitation was performed 628 
      times during the 48-month study period. Of 514 CPA survivors, 18 (3.5%) had MRI 
      studies. The median age was 62 years (interquartile range [IQR], 49-73), and 10 
      were men. Median code duration was 16 minutes (IQR, 11-19 minutes), and median 
      code-to-scan time was 72 hours (IQR, 28-229 hours). A DWI abnormality was noted 
      in 9 (50%) of 18 patients. Cortical areas (global and regional) were the most 
      common sites of restricted diffusion. Diffusion-weighted imaging abnormalities 
      were present in 7 (70%) of 10 patients with a poor neurologic outcome at 
      discharge. CONCLUSION: Magnetic resonance imaging is performed rarely after 
      survival of CPA. In this study with limited sample size, a greater proportion of 
      patients with normal DWI findings had a good neurologic outcome at the time of 
      hospital discharge vs those with abnormal findings. Prospective studies of early 
      and serial MRI (with DWI) are needed to confirm this association and to clarify 
      the prognostic usefulness of such studies.
FAU - Barrett, Kevin M
AU  - Barrett KM
AD  - Department of Neurology, College of Medicine, Mayo Clinic, Jacksonville, FL 
      32224, USA.
FAU - Freeman, William D
AU  - Freeman WD
FAU - Weindling, Steven M
AU  - Weindling SM
FAU - Brott, Thomas G
AU  - Brott TG
FAU - Broderick, Daniel F
AU  - Broderick DF
FAU - Heckman, Michael G
AU  - Heckman MG
FAU - Crook, Julia E
AU  - Crook JE
FAU - Divertie, Gavin D
AU  - Divertie GD
FAU - Meschia, James F
AU  - Meschia JF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Injuries/classification/diagnosis/*etiology
MH  - Cardiopulmonary Resuscitation
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke/*complications/therapy
EDAT- 2007/07/04 09:00
MHDA- 2007/08/03 09:00
CRDT- 2007/07/04 09:00
PHST- 2007/07/04 09:00 [pubmed]
PHST- 2007/08/03 09:00 [medline]
PHST- 2007/07/04 09:00 [entrez]
AID - S0025-6196(11)61307-4 [pii]
AID - 10.4065/82.7.828 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2007 Jul;82(7):828-35. doi: 10.4065/82.7.828.