PMID- 17606442
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20190608
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Linking)
VI  - 92
IP  - 7
DP  - 2007 Jul
TI  - The pattern of genomic gains in salivary gland MALT lymphomas.
PG  - 921-7
AB  - BACKGROUND AND OBJECTIVES: Salivary gland mucosa-associated lymphoid tissue 
      (MALT) lymphomas typically lack chromosomal translocations and the molecular 
      genetics underlying their development is unknown. The aim of this sudy was to 
      investigate chromosomal changes in these lymphomas. DESIGN AND METHODS: We 
      performed comparative genomic hybridisation using DNA samples extracted from 
      microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent 
      chromosomal changes were further verified by interphase fluorescence in situ 
      hybridization (FISH). RESULTS: Chromosomal gains were much more common than 
      losses. Recurrent gains were found at 1p32-ter (42%), 9q33-34 (84%), 11q11-13 
      (42%), 17 (58%) and 18q21-22 (42%). Among these, the recurrent gains at 9q34, 
      11q11-13 and 18q21 were nearly the exclusive gain of the corresponding 
      chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently 
      concurrent, with 12/19 cases affecting at least two of the three loci. The 
      genomic gains at these chromosomal regions were further confirmed by interphase 
      FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), 
      and MALT1 (18q21) loci. INTERPRETATION AND CONCLUSIONS: Salivary gland MALT 
      lymphomas show a conserved pattern of chromosomal gains, which appear to target 
      genes positively modulating cell survival and proliferation.
FAU - Zhou, Yuanping
AU  - Zhou Y
AD  - Division of Molecular Histopathology, Department of Pathology University of 
      Cambridge, Cambridge, United Kingdom.
FAU - Ye, Hongtao
AU  - Ye H
FAU - Martin-Subero, Jose I
AU  - Martin-Subero JI
FAU - Gesk, Stefan
AU  - Gesk S
FAU - Hamoudi, Rifat
AU  - Hamoudi R
FAU - Lu, Yong-Jie
AU  - Lu YJ
FAU - Wang, Rubin
AU  - Wang R
FAU - Shipley, Janet
AU  - Shipley J
FAU - Siebert, Reiner
AU  - Siebert R
FAU - Isaacson, Peter G
AU  - Isaacson PG
FAU - Dogan, Ahmet
AU  - Dogan A
FAU - Du, Ming-Qing
AU  - Du MQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
SB  - IM
MH  - Cell Proliferation
MH  - Cell Survival/genetics
MH  - *Chromosome Aberrations
MH  - Genome, Human
MH  - Humans
MH  - In Situ Hybridization
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Salivary Gland Neoplasms/*genetics
EDAT- 2007/07/04 09:00
MHDA- 2007/09/21 09:00
CRDT- 2007/07/04 09:00
PHST- 2007/07/04 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/07/04 09:00 [entrez]
AID - 10.3324/haematol.10191 [doi]
PST - ppublish
SO  - Haematologica. 2007 Jul;92(7):921-7. doi: 10.3324/haematol.10191.