PMID- 17607379
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20220801
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 13
IP  - 2
DP  - 2007
TI  - Persistent long-term human herpesvirus 6 (HHV-6) infection in a patient with 
      langerhans cell histiocytosis.
PG  - 157-60
AB  - Langerhans cell histiocytosis (eosinophilic granuloma) was first diagnosed in the 
      adolescence of a male patient presented. Several years later persisting human 
      herpesvirus 6 (HHV-6) infection was recognized. The HHV-6 infection could be 
      verified retrospectively in his historical histological samples; the continuous 
      presence of HHV-6 could be established through 17 years of disease course. The 
      patient was operated several times during this period for painful relapses, and 
      developed diabetes insipidus. At variable time points during the clinical course, 
      Varicella zoster (VZV), Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) 
      infections were temporarily detected from blood samples and biopsy specimens. 
      HHV-6 was the only virus continuously identified throughout the entire follow-up 
      period. Antiviral therapy effectively cleared EBV and HHV-8, but HHV-6 remained 
      detectable throughout the disease course. Since DNA sequences of HHV-6 could be 
      detected in the pathologic histiocytes of eosinophilic granuloma, and from other 
      samples taken later on, it is suggested that long-term HHV-6 infection may be 
      associated with development or progression of Langerhans cell histiocytosis.
FAU - Csire, Marta
AU  - Csire M
AD  - Division of Virology, National Center for Epidemiology, Budapest, H-1097, 
      Hungary. mcsire@freemail.hu
FAU - Mikala, Gabor
AU  - Mikala G
FAU - Jako, Janos
AU  - Jako J
FAU - Masszi, Tamas
AU  - Masszi T
FAU - Janosi, Judit
AU  - Janosi J
FAU - Dolgos, Janos
AU  - Dolgos J
FAU - Fule, Tibor
AU  - Fule T
FAU - Tordai, Attila
AU  - Tordai A
FAU - Berencsi, Gyorgy
AU  - Berencsi G
FAU - Valyi-Nagy, Istvan
AU  - Valyi-Nagy I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20070703
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Antiviral Agents)
SB  - IM
CIN - Pathol Oncol Res. 2010 Mar;16(1):125-6. PMID: 19731091
MH  - Adult
MH  - Antiviral Agents/therapeutic use
MH  - Disease Progression
MH  - Herpesvirus 6, Human/*pathogenicity
MH  - Histiocytosis, Langerhans-Cell/*complications/pathology/virology
MH  - Humans
MH  - Langerhans Cells/pathology/virology
MH  - Male
MH  - Roseolovirus Infections/drug therapy/*etiology/pathology
EDAT- 2007/07/04 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/07/04 09:00
PHST- 2006/08/30 00:00 [received]
PHST- 2007/03/10 00:00 [accepted]
PHST- 2007/07/04 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/07/04 09:00 [entrez]
AID - 10.1007/BF02893493 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2007;13(2):157-60. doi: 10.1007/BF02893493. Epub 2007 Jul 3.