PMID- 17607388
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20070703
IS  - 1464-0325 (Print)
IS  - 1464-0325 (Linking)
VI  - 9
IP  - 7
DP  - 2007 Jul
TI  - POP exposure from fish liver consumption and risk of cancer--the Norwegian Women 
      and Cancer Study.
PG  - 682-6
AB  - The aim of the study was to investigate the hypothesis that consumption of fish 
      liver increases cancer risk in humans due to increased intake of persistent 
      organic pollutants (POPs). This study is based on data from the Norwegian Women 
      and Cancer Study (NOWAC). The study has a prospective cohort design with 
      questionnaire data from 64 285 randomly selected Norwegian women (aged 40-70 at 
      baseline) and linkage to the Norwegian Cancer Registry. Cox proportional hazards 
      regression was used to calculate risk ratios associated with consumption of fish 
      liver and total cancer and cancer in breast, uterus, and colon. Fish liver 
      consumption was, after adjusting for known risk factors, associated with a 
      significant reduced risk for total cancer (RR = 0.92, 95% CI: 0.85, 0.99), and 
      non-significant reduced risk for breast cancer (RR = 0.90, 95% CI: 0.78, 1.04), 
      and colon cancer (RR = 0.82, 95% CI: 0.63, 1.07). Relative risk for uterus cancer 
      was 0.82 (95% CI: 0.61-1.12). No significant dose-response effect was found for 
      frequency of fish liver consumption (when divided into three intake groups) and 
      total cancer, nor for any of the other cancer sites.We have concluded that in 
      Norwegian women, fish liver consumption was not associated with an increased 
      cancer risk in breast, uterus, or colon. In contrast, a decreased risk for total 
      cancer was found.
FAU - Brustad, Magritt
AU  - Brustad M
AD  - Institute of Community Medicine, University of Tromso, N-9037 Tromso, Norway. 
      magritt.brustad@ism.uit.no
FAU - Sandanger, Torkjel Manning
AU  - Sandanger TM
FAU - Andersen, Vegard
AU  - Andersen V
FAU - Lund, Eiliv
AU  - Lund E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070518
PL  - England
TA  - J Environ Monit
JT  - Journal of environmental monitoring : JEM
JID - 100968688
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Breast Neoplasms/*epidemiology/etiology
MH  - Colonic Neoplasms/*epidemiology/etiology
MH  - Diet Surveys
MH  - Environmental Exposure
MH  - Female
MH  - *Fishes
MH  - *Food Contamination
MH  - Humans
MH  - *Liver
MH  - Middle Aged
MH  - Norway/epidemiology
MH  - Risk
MH  - Uterine Neoplasms/*epidemiology/etiology
MH  - Water Pollutants, Chemical
EDAT- 2007/07/04 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/07/04 09:00
PHST- 2007/07/04 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/07/04 09:00 [entrez]
AID - 10.1039/b706302b [doi]
PST - ppublish
SO  - J Environ Monit. 2007 Jul;9(7):682-6. doi: 10.1039/b706302b. Epub 2007 May 18.