PMID- 1760843
OWN - NLM
STAT- MEDLINE
DCOM- 19920211
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 67
IP  - 6
DP  - 1991 Dec 20
TI  - The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as 
      a master regulator of CNS midline development.
PG  - 1157-67
AB  - Development of the Drosophila CNS midline cells is dependent upon the function of 
      the single-minded (sim) gene. Sequence analysis shows that sim is a member of the 
      basic-helix-loop-helix class of transcription factors. Cell fate experiments 
      establish that sim is required for early events in midline cell development, 
      including a synchronized cell division, proper formation of nerve cell 
      precursors, and positive auto-regulation of its midline expression. Induction of 
      ectopic sim protein under the control of the hsp70 promoter shows that sim can 
      direct cells of the lateral CNS to exhibit midline cell morphology and patterns 
      of gene expression. We propose that sim functions as a master developmental 
      regulator of the CNS midline lineage.
FAU - Nambu, J R
AU  - Nambu JR
AD  - Department of Biology, University of California, Los Angeles 90024.
FAU - Lewis, J O
AU  - Lewis JO
FAU - Wharton, K A Jr
AU  - Wharton KA Jr
FAU - Crews, S T
AU  - Crews ST
LA  - eng
GR  - GM-07185/GM/NIGMS NIH HHS/United States
GR  - GM-08042/GM/NIGMS NIH HHS/United States
GR  - R01 HD25251/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
GS  - Lc
GS  - MyoD
GS  - arnt
GS  - c-myc
GS  - da
GS  - lyl-1
GS  - sim
GS  - twist
MH  - Amino Acid Sequence
MH  - Animals
MH  - Central Nervous System/*embryology
MH  - DNA Mutational Analysis
MH  - DNA-Binding Proteins/*physiology
MH  - Drosophila melanogaster/embryology/*genetics
MH  - Gene Expression
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*physiology
MH  - RNA, Messenger/genetics
MH  - Sequence Alignment
MH  - Transcription Factors/*physiology
EDAT- 1991/12/30 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/12/30 19:15
PHST- 1991/12/30 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/12/30 19:15 [entrez]
AID - 0092-8674(91)90292-7 [pii]
AID - 10.1016/0092-8674(91)90292-7 [doi]
PST - ppublish
SO  - Cell. 1991 Dec 20;67(6):1157-67. doi: 10.1016/0092-8674(91)90292-7.