PMID- 17608587
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20220310
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 78
IP  - 7
DP  - 2007 Jul
TI  - Effect of 17beta-estradiol and alendronate on the removal torque of 
      osseointegrated titanium implants in ovariectomized rats.
PG  - 1316-21
AB  - BACKGROUND: This study investigated the influence of estrogen deficiency and its 
      treatment with estrogen and alendronate on the removal torque of osseointegrated 
      titanium implants. METHODS: Fifty-eight female Wistar rats received a titanium 
      implant in the tibia metaphysis. After 60 days, which was needed for implant 
      osseointegration, the animals were randomly divided into five groups: control 
      (CTLE; N = 10), sham surgery (SHAM; N = 12), ovariectomy (OVX; N = 12), 
      ovariectomy followed by hormone replacement (EST; N = 12), and ovariectomy 
      followed by treatment with alendronate (ALE; N = 12). The CTLE group was 
      sacrificed to confirm osseointegration, whereas the remaining groups were 
      submitted to sham surgery or ovariectomy according to their designations. After 
      90 days, these animals were also sacrificed. Densitometry of femur and lumbar 
      vertebrae was performed by dual-energy x-ray absorptiometry (DXA) to confirm 
      systemic impairment of the animals. All implants were subjected to removal 
      torque. RESULTS: Densitometric analysis of the femur and lumbar vertebrae 
      confirmed a systemic impairment of the animals, disclosing lower values of bone 
      mineral density for OVX. Analysis of the removal torque of the implants showed 
      statistically lower values (P <0.05) for the OVX group in relation to the other 
      groups. However, the group treated with alendronate (ALE group) presented 
      significantly higher torque values compared to the others. CONCLUSION: According 
      to this study, estrogen deficiency was observed to have a negative influence on 
      the removal torque of osseointegrated implants, whereas treatment with 
      alendronate increased the torque needed to remove the implants.
FAU - Giro, Gabriela
AU  - Giro G
AD  - Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, 
      State University of Sao Paulo, Araraquara, SP, Brazil.
FAU - Sakakura, Celso Eduardo
AU  - Sakakura CE
FAU - Goncalves, Daniela
AU  - Goncalves D
FAU - Pereira, Rosa M R
AU  - Pereira RM
FAU - Marcantonio, Elcio Jr
AU  - Marcantonio E Jr
FAU - Orrico, Silvana R P
AU  - Orrico SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Dental Implants)
RN  - 4TI98Z838E (Estradiol)
RN  - X1J18R4W8P (Alendronate)
SB  - IM
MH  - Alendronate/*pharmacology
MH  - Animals
MH  - Bone Density/drug effects/physiology
MH  - Bone Density Conservation Agents/*pharmacology
MH  - Bone Regeneration/drug effects/physiology
MH  - *Dental Implants
MH  - Dental Stress Analysis
MH  - Drug Interactions
MH  - Estradiol/deficiency/*physiology
MH  - Female
MH  - Osseointegration/*drug effects/physiology
MH  - Osteoporosis/physiopathology/prevention & control
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Torque
EDAT- 2007/07/05 09:00
MHDA- 2007/10/20 09:00
CRDT- 2007/07/05 09:00
PHST- 2007/07/05 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2007/07/05 09:00 [entrez]
AID - 10.1902/jop.2007.060390 [doi]
PST - ppublish
SO  - J Periodontol. 2007 Jul;78(7):1316-21. doi: 10.1902/jop.2007.060390.