PMID- 17608772
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20161124
IS  - 1347-9032 (Print)
IS  - 1347-9032 (Linking)
VI  - 98
IP  - 9
DP  - 2007 Sep
TI  - Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 
      alpha under hypoxia.
PG  - 1476-81
AB  - Hypoxia is a state of deficiency of available oxygen in the blood and tissues, 
      and it occurs during several pathophysiological processes, including 
      tumorigenesis. Under hypoxia, hypoxia-inducible factor-1 (HIF-1) plays an 
      essential role in cellular oxygen homeostasis. In the present article protein 
      kinase C-delta (PKC-delta) is activated by hypoxia, increases the protein 
      stability and transcriptional activity of HIF-1alpha in human cervical 
      adenocarcinoma cells. Moreover, the knockdown of PKC-delta inhibited vascular 
      endothelial growth factor expression and angiogenic activity under hypoxia. These 
      effects were completely reversed by PKC-delta overexpression following the 
      knockdown of PKC-delta. Collectively, these findings demonstrate the role of 
      PKC-delta as a new regulator of hypoxia-induced angiogenesis.
FAU - Lee, Ji-Won
AU  - Lee JW
AD  - Neurovascular Coordination Research Center and Research Institute of 
      Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 
      151-742, Korea.
FAU - Park, Jeong Ae
AU  - Park JA
FAU - Kim, Se-Hee
AU  - Kim SH
FAU - Seo, Ji Hae
AU  - Seo JH
FAU - Lim, Kyung-Joon
AU  - Lim KJ
FAU - Jeong, Joo-Won
AU  - Jeong JW
FAU - Jeong, Chul-Ho
AU  - Jeong CH
FAU - Chun, Kwang-Hoon
AU  - Chun KH
FAU - Lee, Seung-Ki
AU  - Lee SK
FAU - Kwon, Young-Guen
AU  - Kwon YG
FAU - Kim, Kyu-Won
AU  - Kim KW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070630
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - EC 2.7.11.13 (Protein Kinase C-delta)
SB  - IM
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Enzyme Activation/genetics
MH  - Gene Expression Regulation, Enzymologic
MH  - HeLa Cells
MH  - Humans
MH  - Hypoxia/enzymology/genetics/*metabolism/physiopathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*chemistry/genetics/*metabolism
MH  - Neovascularization, Pathologic/enzymology/genetics/metabolism/physiopathology
MH  - Protein Kinase C-delta/*physiology
MH  - Transcriptional Activation
EDAT- 2007/07/05 09:00
MHDA- 2007/10/18 09:00
CRDT- 2007/07/05 09:00
PHST- 2007/07/05 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/07/05 09:00 [entrez]
AID - CAS535 [pii]
AID - 10.1111/j.1349-7006.2007.00535.x [doi]
PST - ppublish
SO  - Cancer Sci. 2007 Sep;98(9):1476-81. doi: 10.1111/j.1349-7006.2007.00535.x. Epub 
      2007 Jun 30.