PMID- 17610331
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20181113
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 8
IP  - 7
DP  - 2007 Jul
TI  - Simultaneous determination of fluoride, chloride, sulfate, phosphate, 
      monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion 
      chromatography.
PG  - 507-11
AB  - Simple, reliable and sensitive analytical methods to determine anticariogenic 
      agents, preservatives, and artificial sweeteners contained in commercial gargles 
      are necessary for evaluating their effectiveness, safety, and quality. An ion 
      chromatography (IC) method has been described to analyze simultaneously eight 
      anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate, 
      glycerophosphate (anticariogenic agents), sorbate (a preservative), and saccharin 
      (an artificial sweetener) in gargles. In this IC system, we applied a mobile 
      phased gradient elution with KOH, separation by IonPac AS18 columns, and 
      suppressed conductivity detection. Optimized analytical conditions were further 
      evaluated for accuracy. The relative standard deviations (RSDs) of the 
      inter-day's retention time and peak area of all species were less than 0.938% and 
      8.731%, respectively, while RSDs of 5-day retention time and peak area were less 
      than 1.265% and 8.934%, respectively. The correlation coefficients for targeted 
      analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions 
      were 90% approximately 102.5%. We concluded that the method can be applied for 
      comprehensive evaluation of commercial gargles.
FAU - Zhang, Yan-zhen
AU  - Zhang YZ
AD  - Department of Stomatology, Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310009, China. zyz85@hotmail.com
FAU - Zhou, Yan-chun
AU  - Zhou YC
FAU - Liu, Li
AU  - Liu L
FAU - Zhu, Yan
AU  - Zhu Y
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Cariostatic Agents)
RN  - 0 (Chlorides)
RN  - 0 (Glycerophosphates)
RN  - 0 (Mouthwashes)
RN  - 0 (Phosphates)
RN  - 0 (Preservatives, Pharmaceutical)
RN  - 0 (Sulfates)
RN  - 0 (Sweetening Agents)
RN  - 15181-43-8 (fluorophosphate)
RN  - FST467XS7D (Saccharin)
RN  - Q80VPU408O (Fluorides)
RN  - X045WJ989B (Sorbic Acid)
SB  - IM
MH  - Cariostatic Agents/*analysis
MH  - Chlorides/analysis
MH  - Chromatography, Ion Exchange/*methods
MH  - Dental Caries/prevention & control
MH  - Fluorides/analysis
MH  - Glycerophosphates/analysis
MH  - Humans
MH  - Mouthwashes/*analysis
MH  - Phosphates/analysis
MH  - Preservatives, Pharmaceutical/analysis
MH  - Saccharin/analysis
MH  - Sorbic Acid/analysis
MH  - Sulfates/analysis
MH  - Sweetening Agents/analysis
PMC - PMC1906597
EDAT- 2007/07/05 09:00
MHDA- 2007/08/31 09:00
PMCR- 2007/07/01
CRDT- 2007/07/05 09:00
PHST- 2007/07/05 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2007/07/05 09:00 [entrez]
PHST- 2007/07/01 00:00 [pmc-release]
AID - 10.1631/jzus.2007.B0507 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2007 Jul;8(7):507-11. doi: 10.1631/jzus.2007.B0507.