PMID- 17611164
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20131121
IS  - 1526-5900 (Print)
IS  - 1526-5900 (Linking)
VI  - 8
IP  - 9
DP  - 2007 Sep
TI  - Increased levels of neurotrophins are not specific for chronic migraine: evidence 
      from primary fibromyalgia syndrome.
PG  - 737-45
AB  - All data obtained in experimental animal pain models support the role of nerve 
      growth factor (NGF) as a putative candidate intervening in the pathogenesis of 
      chronic pain, including chronic daily headache (CDH). Few studies have been 
      carried out to establish its role in maintaining pain states in humans. The 
      present study was aimed at investigating cerebrospinal fluid (CSF) levels of NGF 
      and brain-derived neurotrophic factor (BDNF), both measured by sensitive 
      immunoassay, in 20 chronic migraine (CM) patients and 20 patients affected by 
      primary fibromyalgia syndrome (PFMS), compared with those of 20 age-matched 
      control subjects. Significantly higher levels of both neurotrophins and glutamate 
      were found. A significantly positive correlation emerged between CSF values of 
      BDNF and those of NGF (r = .61, P < .001; r = .53, P < .01) and glutamate (r = 
      .44, P < .02; r = .51, P < .01) in CM and PFMS patients, respectively. These 
      findings suggest the possibility of a NGF-mediated up-regulation of BDNF involved 
      in the pathophysiological events underlying long-term neuroplastic changes in 
      persistent chronic painful conditions, such as CM and fibromyalgia. NGF might 
      indirectly exert its effect through enhancing glutamatergic transmission via 
      BDNF. The above mechanisms could account for sustained central sensitization in 
      both chronic pain states. PERSPECTIVE: This article presents findings of higher 
      NGF and BDNF levels correlated to increased glutamate levels in the CSF of both 
      chronic migraine and fibromyalgia patients. This opens new insights into the 
      pathogenic mechanisms of chronic pain and offers clinicians new therapeutic 
      perspectives targeting the above mechanisms in both painful disorders.
FAU - Sarchielli, Paola
AU  - Sarchielli P
AD  - Neurologic Clinic, Department of Medical and Surgical Specialties and Public 
      Health, University of Perugia, Perugia, Italy. neuro.pg@tiscalinet.it
FAU - Mancini, Maria Luisa
AU  - Mancini ML
FAU - Floridi, Alessandro
AU  - Floridi A
FAU - Coppola, Francesca
AU  - Coppola F
FAU - Rossi, Cristiana
AU  - Rossi C
FAU - Nardi, Katiuscia
AU  - Nardi K
FAU - Acciarresi, Monica
AU  - Acciarresi M
FAU - Pini, Luigi Alberto
AU  - Pini LA
FAU - Calabresi, Paolo
AU  - Calabresi P
LA  - eng
PT  - Journal Article
DEP - 20070705
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Brain/metabolism/physiopathology
MH  - Brain Chemistry/physiology
MH  - Brain-Derived Neurotrophic Factor/analysis/cerebrospinal fluid
MH  - Chronic Disease
MH  - Female
MH  - Fibromyalgia/*cerebrospinal fluid/*physiopathology
MH  - Glutamic Acid/analysis/*cerebrospinal fluid
MH  - Humans
MH  - Immunoassay
MH  - Male
MH  - Migraine Disorders/*cerebrospinal fluid/*physiopathology
MH  - Nerve Growth Factor/analysis/cerebrospinal fluid
MH  - Nerve Growth Factors/analysis/*cerebrospinal fluid
MH  - Predictive Value of Tests
MH  - Synaptic Transmission/physiology
MH  - Up-Regulation/physiology
EDAT- 2007/07/06 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/06 09:00
PHST- 2006/12/08 00:00 [received]
PHST- 2007/05/01 00:00 [revised]
PHST- 2007/05/08 00:00 [accepted]
PHST- 2007/07/06 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/06 09:00 [entrez]
AID - S1526-5900(07)00689-X [pii]
AID - 10.1016/j.jpain.2007.05.002 [doi]
PST - ppublish
SO  - J Pain. 2007 Sep;8(9):737-45. doi: 10.1016/j.jpain.2007.05.002. Epub 2007 Jul 5.