PMID- 17611278
OWN - NLM
STAT- MEDLINE
DCOM- 20070802
LR  - 20250529
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 27
IP  - 27
DP  - 2007 Jul 4
TI  - Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent 
      refinement of neuronal pathways in retina.
PG  - 7256-67
AB  - Sensory experience refines neuronal structure and functionality. The visual 
      system has proved to be a productive model system to study this plasticity. In 
      the neonatal retina, the dendritic arbors of a large proportion of ganglion cells 
      are diffuse in the inner plexiform layer. With maturation, many of these arbors 
      become monolaminated. Visual deprivation suppresses this remodeling. Little is 
      known of the molecular mechanisms controlling maturational and 
      experience-dependent refinement. Here, we tested the hypothesis that 
      brain-derived neurotrophic factor (BDNF), which is known to regulate dendritic 
      branching and synaptic function in the brain, modulates the developmental and 
      visual experience-dependent refinement of retinal ganglion cells. We used a 
      transgenic mouse line, in which a small number of ganglion cells were labeled 
      with yellow fluorescence protein, to delineate their dendritic structure in vivo. 
      We found that transgenic overexpression of BDNF accelerated the laminar 
      refinement of ganglion cell dendrites, whereas decreased TrkB expression or 
      retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it. 
      BDNF-TrkB signaling regulated the maturational formation of new branches in ON 
      but not the bilaminated ON-OFF ganglion cells. Furthermore, BDNF overexpression 
      overrides the requirement for visual inputs to stimulate laminar refinement and 
      dendritic branching of ganglion cells. These experiments reveal a previously 
      unrecognized action of BDNF and TrkB in controlling cell-specific, 
      experience-dependent remodeling of neuronal structures in the visual system.
FAU - Liu, Xiaorong
AU  - Liu X
AD  - Department of Ophthalmology, University of California, San Francisco, San 
      Francisco, California 94143, USA.
FAU - Grishanin, Ruslan N
AU  - Grishanin RN
FAU - Tolwani, Ravi J
AU  - Tolwani RJ
FAU - Renteria, Rene C
AU  - Renteria RC
FAU - Xu, Baoji
AU  - Xu B
FAU - Reichardt, Louis F
AU  - Reichardt LF
FAU - Copenhagen, David R
AU  - Copenhagen DR
LA  - eng
GR  - P01 NS016033/NS/NINDS NIH HHS/United States
GR  - P30 EY002162/EY/NEI NIH HHS/United States
GR  - R01 EY001869/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics/*physiology
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Rats
MH  - Receptor, trkB/biosynthesis/genetics/*physiology
MH  - Retina/*growth & development/*metabolism/physiology
MH  - Sensory Deprivation/physiology
MH  - Vision, Ocular/physiology
MH  - Visual Pathways/*growth & development/*metabolism/physiology
PMC - PMC2579893
MID - NIHMS52165
EDAT- 2007/07/06 09:00
MHDA- 2007/08/03 09:00
PMCR- 2008/01/04
CRDT- 2007/07/06 09:00
PHST- 2007/07/06 09:00 [pubmed]
PHST- 2007/08/03 09:00 [medline]
PHST- 2007/07/06 09:00 [entrez]
PHST- 2008/01/04 00:00 [pmc-release]
AID - 27/27/7256 [pii]
AID - 3242786 [pii]
AID - 10.1523/JNEUROSCI.0779-07.2007 [doi]
PST - ppublish
SO  - J Neurosci. 2007 Jul 4;27(27):7256-67. doi: 10.1523/JNEUROSCI.0779-07.2007.