PMID- 1761187
OWN - NLM
STAT- MEDLINE
DCOM- 19920213
LR  - 20190824
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 22
IP  - 5
DP  - 1991
TI  - Participation of opioid peptide (beta-endorphin) and norepinephrine in the 
      control of compound 48/80-induced hypovolemic thirst in the rats.
PG  - 825-9
AB  - 1. Subcutaneous (s.c.) administration of compound 48/80 elicited the increases of 
      water intake, plasma beta-endorphin-like immunoreactivity, hypothalamic 
      3-methoxy-4-hydroxyphenylethyleneglycol sulfate and Hct in the rats. 2. The s.c. 
      pretreatment of naloxone reduced the compound 48/80-induced water intake but had 
      no effects on other variables. 3. Intracerebroventricular (i.c.v.) injection of 
      naloxone attenuated the compound 48/80- and i.c.v. injected angiotensin II (ANG 
      II)-induced water intake. 4. The hypothalamic norepinephrine metabolism was 
      increased by s.c. injection of compound 48/80 but not by i.c.v. ANG II. 5. The 
      present data suggest the possible involvement of opioid peptide (beta-endorphin) 
      on the compound 48/80- and ANG II-induced thirst. However, it is uncertain 
      whether hypothalamic norepinephrine is involved in the hypovolemic thirst 
      mediated via stimulation of renin-angiotensin system.
FAU - Izumi, H
AU  - Izumi H
AD  - Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Catecholamines)
RN  - 11128-99-7 (Angiotensin II)
RN  - 36B82AMQ7N (Naloxone)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 60617-12-1 (beta-Endorphin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Angiotensin II/administration & dosage/pharmacology
MH  - Animals
MH  - Blood Volume/*physiology
MH  - Catecholamines/metabolism
MH  - Hypothalamus/drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Male
MH  - Methoxyhydroxyphenylglycol/metabolism
MH  - Naloxone/administration & dosage/pharmacology
MH  - Norepinephrine/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thirst/*drug effects
MH  - beta-Endorphin/*physiology
MH  - p-Methoxy-N-methylphenethylamine/administration & dosage/*pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0306-3623(91)90214-Q [pii]
AID - 10.1016/0306-3623(91)90214-q [doi]
PST - ppublish
SO  - Gen Pharmacol. 1991;22(5):825-9. doi: 10.1016/0306-3623(91)90214-q.