PMID- 17613175
OWN - NLM
STAT- MEDLINE
DCOM- 20071213
LR  - 20181113
IS  - 1053-8569 (Print)
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 16
IP  - 9
DP  - 2007 Sep
TI  - National surveillance of herbal dietary supplement exposures: the poison control 
      center experience.
PG  - 947-57
AB  - PURPOSE: The purpose of this report is to characterize reports to poison control 
      centers (PCCs) involving two widely used herbal dietary supplements (HDSs), 
      Echinacea, and St. John's wort (SJW). METHODS: We purchased data from the 
      American Association of Poison Control Center's (AAPCC) toxic exposure 
      surveillance system (TESS(R)) on reports made to PCCs in 2001 involving Echinacea 
      or SJW. Analyses were limited to those cases in which Echinacea or SJW were the 
      only associated products, and in which these HDSs were deemed primary to observed 
      adverse effects. Descriptive statistics were generated for selected demographic 
      and exposure-related variables. RESULTS: During 2001, PCCs were contacted 
      regarding 406 exposures involving Echinacea and 356 exposures involving SJW. Most 
      of the reported exposures for both HDSs occurred among children 5 years and 
      younger, and the majority of exposures were coded as unintentional. For both 
      HDSs, exposures among patients >/=20 years old were more likely to be associated 
      with adverse effects. Intentional exposures accounted for 21% of SJW cases and 3% 
      of Echinacea cases, with 13% of SJW exposures reported as 'suspected suicidal'. 
      CONCLUSIONS: TESS represents a potentially important means of assessing and 
      characterizing HDS-related adverse effects. Detailed studies validating the 
      clinical events and outcomes of a sample of exposures reported to TESS(R) might 
      offer substantial insights into adverse events (AEs) that could be systematically 
      studied with other, established pharmacoepidemiological study designs.
CI  - Copyright (c) 2007 John Wiley & Sons, Ltd.
FAU - Gryzlak, Brian M
AU  - Gryzlak BM
AD  - Department of Epidemiology, University of Iowa, IA, USA.
FAU - Wallace, Robert B
AU  - Wallace RB
FAU - Zimmerman, M Bridget
AU  - Zimmerman MB
FAU - Nisly, Nicole L
AU  - Nisly NL
LA  - eng
GR  - P01 ES012020/ES/NIEHS NIH HHS/United States
GR  - P01 ES012020-05/ES/NIEHS NIH HHS/United States
GR  - P50 AT004155/AT/NCCIH NIH HHS/United States
GR  - 9 P50 AT004155-06/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
SB  - IM
CIN - Pharmacoepidemiol Drug Saf. 2007 Sep;16(9):958-60. PMID: 17705239
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual/statistics & numerical data
MH  - Dietary Supplements/*adverse effects/economics/statistics & numerical data
MH  - Drug Therapy/methods/standards
MH  - Drug-Related Side Effects and Adverse Reactions/epidemiology/etiology
MH  - Echinacea/adverse effects/classification
MH  - Female
MH  - Humans
MH  - Hypericum/adverse effects
MH  - Male
MH  - Phytotherapy/*adverse effects/economics/statistics & numerical data
MH  - Poison Control Centers/*statistics & numerical data
MH  - Product Surveillance, Postmarketing/economics/methods/*statistics & numerical 
      data
MH  - Suicide, Attempted/statistics & numerical data
MH  - Time Factors
MH  - United States/epidemiology
PMC - PMC2265591
MID - NIHMS41050
COIS- No authors report any interpretive, financial, or other conflicts of interest in 
      any aspect of preparation of this manuscript. Its contents are solely the 
      responsibility of the authors and do not necessarily represent the official views 
      of the NIEHS, NIH.
EDAT- 2007/07/07 09:00
MHDA- 2007/12/14 09:00
PMCR- 2008/03/07
CRDT- 2007/07/07 09:00
PHST- 2007/07/07 09:00 [pubmed]
PHST- 2007/12/14 09:00 [medline]
PHST- 2007/07/07 09:00 [entrez]
PHST- 2008/03/07 00:00 [pmc-release]
AID - 10.1002/pds.1445 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2007 Sep;16(9):947-57. doi: 10.1002/pds.1445.