PMID- 17613405
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20070706
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 26
IP  - 7
DP  - 2007 Jul
TI  - Creation of a model comparing 6-minute walk test to metabolic equivalent in 
      evaluating treatment effects in pulmonary arterial hypertension.
PG  - 732-8
AB  - BACKGROUND: The 6-minute walk test (6MWT) is the current standard to assess 
      exercise capacity in pulmonary arterial hypertension (PAH). We compared the 
      Naughton-Balke treadmill test reported in exercise metabolic equivalents (METs) 
      with the 6MWT to evaluate whether MET could be a useful tool to assess exercise 
      capacity. METHODS: Serial 6MWTs followed by Naughton-Balke treadmill tests were 
      performed in 47 PAH patients initiating a change in PAH therapy at baseline 
      (i.e., Time 0) and Weeks 6, 12, 24 and 48; New York Heart Association (NYHA) 
      functional class (FC) was also assessed. Hemodynamics data were recorded at 
      baseline and Weeks 12 and 48. Treadmill time was converted to MET. Generalized 
      estimating equation models, receiver-operating characteristic curves and 
      fixed-effect linear models were utilized to create a model comparing 6MWT to MET. 
      RESULTS: MET correlated with 6MWT (r = 0.62). Piecewise linear function described 
      the relationship between 6MWT and MET. 6MWT and MET were both associated with FC 
      (p < 0.001) with similar ability to discriminate FC. Changes in hemodynamics in 
      response to a change in PAH therapy correlated with changes in both 6MWT and MET. 
      In less sick patients (i.e., FC II), the changes in 6MWT were less pronounced 
      than with MET. CONCLUSIONS: MET appears to be a reliable measure of exercise 
      capacity in PAH, and correlates with 6MWT. MET can be used in clinical assessment 
      and is helpful in demonstrating improvements in exercise capacity in less sick 
      patients.
FAU - Gomberg-Maitland, Mardi
AU  - Gomberg-Maitland M
AD  - Section of Cardiology, Department of Medicine, University of Chicago, Chicago, 
      Illinois 60637, USA. mgomberg@medicine.bsd.uchicago.edu
FAU - Huo, Dezheng
AU  - Huo D
FAU - Benza, Raymond L
AU  - Benza RL
FAU - McLaughlin, Vallerie V
AU  - McLaughlin VV
FAU - Tapson, Victor F
AU  - Tapson VF
FAU - Barst, Robyn J
AU  - Barst RJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20070613
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/physiology
MH  - Cardiac Output/physiology
MH  - Child
MH  - Endpoint Determination
MH  - Energy Metabolism/physiology
MH  - Exercise Test/*methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology/therapy
MH  - *Linear Models
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Oxygen Consumption/physiology
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Walking/*physiology
EDAT- 2007/07/07 09:00
MHDA- 2007/08/31 09:00
CRDT- 2007/07/07 09:00
PHST- 2006/12/28 00:00 [received]
PHST- 2007/03/15 00:00 [revised]
PHST- 2007/04/13 00:00 [accepted]
PHST- 2007/07/07 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2007/07/07 09:00 [entrez]
AID - S1053-2498(07)00363-4 [pii]
AID - 10.1016/j.healun.2007.04.013 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2007 Jul;26(7):732-8. doi: 10.1016/j.healun.2007.04.013. 
      Epub 2007 Jun 13.