PMID- 17613596
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20070706
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 13
IP  - 6
DP  - 2007 Jul
TI  - Cell surface adhesion molecules and cytokine profiles in primary progressive 
      multiple sclerosis.
PG  - 701-7
AB  - OBJECTIVE: We evaluated the utility of adhesion molecule (AM) and 
      cytokine/chemokine expressions in blood and cerebrospinal fluid (CSF) as markers 
      of disease activity in primary progressive multiple sclerosis (PPMS). METHODS: 
      The expressions of AMs and the levels of 17 cytokines in patients with PPMS (n = 
      25) were compared with those in secondary progressive MS (SPMS) (n = 18) and 
      controls (n =11) and correlated with the volumes of focal and atrophic changes on 
      MRI. RESULTS: The expressions of very late activation antigen 4 (VLA-4), 
      lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion 
      molecule 1 (ICAM-1) in blood and CSF were higher in PPMS than in controls. 
      Comparison between PPMS and SPMS showed higher levels of ICAM-1 in blood and CSF 
      in PPMS, while the level of the vascular adhesion molecule (VCAM-1) was higher 
      only in blood. There was no difference in the levels of cytokines in serum or CSF 
      between PPMS and SPMS or controls, but evidence suggesting intrathecal synthesis 
      of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) was found 
      in PPMS. The expressions of CSF VLA-4 in PPMS correlated with the total volume of 
      cerebral lesions and the number of diffuse brain lesions in MRI, while the amount 
      of LFA-1 in CSF correlated with the number of spinal T2 lesions. The level of 
      serum MIP-1beta correlated with the T2 lesion load and EDSS score in PPMS. 
      CONCLUSIONS: The upregulated expressions of AMs in blood and CSF and evidence for 
      intrathecal synthesis of MCP-1 and IL-8 in PPMS indicate the importance of 
      inflammatory changes in the pathogenesis of PPMS.
FAU - Ukkonen, Maritta
AU  - Ukkonen M
AD  - Department of Neurology, Tampere University Hospital, Tampere, Finland. 
      maritta.ukkonen@pshp.fi
FAU - Wu, Kingchen
AU  - Wu K
FAU - Reipert, Birgit
AU  - Reipert B
FAU - Dastidar, Prasun
AU  - Dastidar P
FAU - Elovaara, Irina
AU  - Elovaara I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070315
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Cell Adhesion Molecules/*blood/cerebrospinal fluid
MH  - Chemokines/blood/cerebrospinal fluid
MH  - Cytokines/*blood/cerebrospinal fluid
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Multiple Sclerosis, Chronic Progressive/*blood/cerebrospinal fluid
MH  - Reference Values
EDAT- 2007/07/07 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/07/07 09:00
PHST- 2007/07/07 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/07/07 09:00 [entrez]
AID - 1352458506075378 [pii]
AID - 10.1177/1352458506075378 [doi]
PST - ppublish
SO  - Mult Scler. 2007 Jul;13(6):701-7. doi: 10.1177/1352458506075378. Epub 2007 Mar 
      15.