PMID- 17613938
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20131121
IS  - 1025-3890 (Print)
IS  - 1025-3890 (Linking)
VI  - 10
IP  - 3
DP  - 2007 Aug
TI  - Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and 
      nitrergic neurotransmitter systems.
PG  - 227-49
AB  - Several findings relate the hippocampal formation to the behavioural consequences 
      of stress. It contains a high concentration of corticoid receptors and undergoes 
      plastic modifications, including decreased neurogenesis and cellular remodelling, 
      following stress exposure. Various major neurotransmitter systems in the 
      hippocampus are involved in these effects. Serotonin (5-HT) seems to exert a 
      protective role in the hippocampus and attenuates the behavioural consequences of 
      stress by activating 5-HT1A receptors in this structure. These effects may 
      mediate the therapeutic actions of several antidepressants. The role of 
      noradrenaline is less clear and possibly depends on the specific hippocampal 
      region (dorsal vs. ventral). The deleterious modifications induced in the 
      hippocampus by stress might involve a decrease in neurotrophic factors such as 
      brain derived neurotrophic factor (BDNF) following glutamate N-methyl-D-aspartate 
      (NMDA) receptor activation. In addition to glutamate, nitric oxide (NO) could 
      also be related to these effects. Systemic and intra-hippocampal administration 
      of nitric oxide synthase (NOS) inhibitors attenuates stress-induced behavioural 
      consequences. The challenge for the future will be to integrate results related 
      to these different neurotransmitter systems in a unifying theory about the role 
      of the hippocampus in mood regulation, depressive disorder and antidepressant 
      effects.
FAU - Joca, Samia Regiane Lourenco
AU  - Joca SR
AD  - Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of 
      Sao Paulo, Ribeirao Preto, SP, Brazil.
FAU - Ferreira, Frederico Rogerio
AU  - Ferreira FR
FAU - Guimaraes, Francisco Silveira
AU  - Guimaraes FS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Stress
JT  - Stress (Amsterdam, Netherlands)
JID - 9617529
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biogenic Monoamines)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adaptation, Psychological
MH  - Affect
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Biogenic Monoamines/*metabolism
MH  - Depression/drug therapy/metabolism
MH  - Dopamine/metabolism
MH  - Glutamic Acid/*metabolism
MH  - Hippocampus/drug effects/*metabolism/pathology
MH  - Humans
MH  - Neurons/drug effects/*metabolism/pathology
MH  - Nitrergic Neurons/drug effects/*metabolism/pathology
MH  - Nitric Oxide/*metabolism
MH  - Norepinephrine/metabolism
MH  - Serotonin/metabolism
MH  - Stress, Psychological/drug therapy/*metabolism/pathology
RF  - 342
EDAT- 2007/07/07 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/07/07 09:00
PHST- 2007/07/07 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/07/07 09:00 [entrez]
AID - 780350706 [pii]
AID - 10.1080/10253890701223130 [doi]
PST - ppublish
SO  - Stress. 2007 Aug;10(3):227-49. doi: 10.1080/10253890701223130.