PMID- 17614817
OWN - NLM
STAT- MEDLINE
DCOM- 20070823
LR  - 20220309
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 138
IP  - 3
DP  - 2007 Aug
TI  - Dendritic cells and myeloid leukaemias: plasticity and commitment in cell 
      differentiation.
PG  - 281-90
AB  - Dendritic cells (DCs) are key antigen-presenting cells (APCs), which link innate 
      and adaptive immunity, ultimately activating antigen-specific T cells. This 
      review examines the relationship between the acute and chronic myeloid leukaemias 
      and cells with DC properties. DCs are non-dividing terminally differentiated 
      cells, and ex vivo leukaemic cells or cell lines show little similarity to DCs. 
      However, many leukaemias differentiate further in response to defined stimuli, 
      and retain a degree of lineage plasticity. Therefore, several studies have 
      explored the response of leukaemic cells to the in vitro regimens used to 
      differentiate ex vivo primary DCs. Recent data suggest that the most 
      'dendritic-like' cells can be derived from more undifferentiated myeloid 
      leukaemias, such as the myelomonocytic Mutz-3 cell line. These findings have 
      important implications for understanding the developmental origins of DCs, for 
      harnessing the APC properties of this class of tumour to stimulate the 
      therapeutic anti-tumour immunity, and for developing useful models for the study 
      of human DC physiology and pathology. There is a strong rationale for further 
      exploration of this class of tumour and its relationship to the normal DC.
FAU - Rasaiyaah, Jane
AU  - Rasaiyaah J
AD  - Department of Immunology and Molecular Pathology, UCL, London, UK.
FAU - Yong, Kwee
AU  - Yong K
FAU - Katz, David R
AU  - Katz DR
FAU - Kellam, Paul
AU  - Kellam P
FAU - Chain, Benjamin M
AU  - Chain BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Acute Disease
MH  - Cell Differentiation
MH  - Cell Line, Tumor
MH  - Cell Lineage
MH  - Chronic Disease
MH  - Dendritic Cells/*pathology
MH  - Humans
MH  - Immunity, Innate
MH  - Immunotherapy, Adoptive
MH  - Leukemia, Myeloid/*pathology
RF  - 66
EDAT- 2007/07/07 09:00
MHDA- 2007/08/24 09:00
CRDT- 2007/07/07 09:00
PHST- 2007/07/07 09:00 [pubmed]
PHST- 2007/08/24 09:00 [medline]
PHST- 2007/07/07 09:00 [entrez]
AID - BJH6622 [pii]
AID - 10.1111/j.1365-2141.2007.06622.x [doi]
PST - ppublish
SO  - Br J Haematol. 2007 Aug;138(3):281-90. doi: 10.1111/j.1365-2141.2007.06622.x.