PMID- 1761757
OWN - NLM
STAT- MEDLINE
DCOM- 19920213
LR  - 20151119
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 313
IP  - 1
DP  - 1991 Nov 1
TI  - Differential expression of mRNAs for the NGF family of neurotrophic factors in 
      the adult rat central olfactory system.
PG  - 95-102
AB  - The cellular localization of mRNAs for nerve growth factor (NGF), brain-derived 
      neurotrophic factor (BDNF), and neurotrophin-3 (NT3), in the rat central 
      olfactory system was evaluated with in situ hybridization of 35S-labeled cRNA 
      probes. In the main olfactory bulb, low levels of NGF and BDNF mRNA expression 
      were detected. NGF mRNA was restricted to the glomerular region while BDNF mRNA 
      was predominantly localized to the granule cell layer. No cellular hybridization 
      to NT3 cRNA was seen. The accessory olfactory bulb did not express detectable 
      levels of mRNA for any of the three related neurotrophic factors. Areas which 
      receive olfactory bulb afferents expressed comparatively high levels of both NGF 
      and BDNF mRNA. Cell labeling with cRNAs for NGF and BDNF occurred throughout the 
      cellular layers of the anterior olfactory nucleus and in layers 2 and 3 of 
      rostral piriform cortex. BDNF mRNA expression in these areas appeared more robust 
      than that of NGF mRNA, while NT3 mRNA was not detectable. In contrast, tenia 
      tecta exhibited dense labeling with the cRNAs for all three neurotrophic factors. 
      The localization of NGF mRNA to primary target neurons of the olfactory nerve in 
      the periglomerular region of the main olfactory bulb suggests that bulb cells may 
      influence the ingrowth and continual turnover of olfactory sensory afferents. 
      However, as there is a strong correlation between the distribution of 
      neurotrophic factor mRNAs within rostral olfactory structures and the 
      distribution of centrifugal cholinergic afferents, it is more likely that 
      bulb-derived NGF, and possibly BDNF, act on the cholinergic neurons of the basal 
      forebrain.
FAU - Guthrie, K M
AU  - Guthrie KM
AD  - Department of Anatomy and Neurobiology, University of California, Irvine 92717.
FAU - Gall, C M
AU  - Gall CM
LA  - eng
GR  - HD24236/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sulfur Radioisotopes)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cerebral Cortex/anatomy & histology/metabolism
MH  - Male
MH  - Nerve Growth Factors/*biosynthesis
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Neurotrophin 3
MH  - Nucleic Acid Hybridization
MH  - Olfactory Bulb/anatomy & histology/*metabolism
MH  - Olfactory Nerve/metabolism
MH  - RNA Probes
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sulfur Radioisotopes
EDAT- 1991/11/01 00:00
MHDA- 1991/11/01 00:01
CRDT- 1991/11/01 00:00
PHST- 1991/11/01 00:00 [pubmed]
PHST- 1991/11/01 00:01 [medline]
PHST- 1991/11/01 00:00 [entrez]
AID - 10.1002/cne.903130107 [doi]
PST - ppublish
SO  - J Comp Neurol. 1991 Nov 1;313(1):95-102. doi: 10.1002/cne.903130107.