PMID- 17618604
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 360
IP  - 3
DP  - 2007 Aug 31
TI  - Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and 
      monocyte-chemoattractant-protein-1 in the diabetic endothelial cell.
PG  - 560-5
AB  - Hyperglycemia is the major cause of diabetic angiopathy. Aim of our study was to 
      evaluate the impact of high glucose on cell growth and function of human 
      "diabetic" endothelial cells (EC). Incubation of non-diabetic EC with glucose 
      moderately inhibited cell growth and increased the expression of ICAM-1 and 
      E-selectin. In the disease-specific EC, glucose treatment resulted also in 
      moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 
      by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) 
      by 40-70%. The expression of ICAM-1 and E-selectin and the release of IL-6 and 
      IL-8 was not affected. The usage of our disease-specific EC model might evaluate 
      the impact of systemic factors of diabetic patients in the progression of 
      endothelial dysfunction, and may be suitable to develop relevant therapeutic 
      regimens.
FAU - Haubner, Frank
AU  - Haubner F
AD  - Department of Cardiothoracic Surgery, University Hospital Regensburg, 
      Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany.
FAU - Lehle, Karla
AU  - Lehle K
FAU - Munzel, Daniela
AU  - Munzel D
FAU - Schmid, Christof
AU  - Schmid C
FAU - Birnbaum, Dietrich E
AU  - Birnbaum DE
FAU - Preuner, Jurgen G
AU  - Preuner JG
LA  - eng
PT  - Journal Article
DEP - 20070618
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Cell Adhesion Molecules/metabolism
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Chemokine CCL2/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Endothelial Cells/drug effects/*metabolism
MH  - Female
MH  - Glucose/pharmacology
MH  - Humans
MH  - Hyperglycemia/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Vascular Cell Adhesion Molecule-1/*metabolism
EDAT- 2007/07/10 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/07/10 09:00
PHST- 2007/06/05 00:00 [received]
PHST- 2007/06/11 00:00 [accepted]
PHST- 2007/07/10 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/07/10 09:00 [entrez]
AID - S0006-291X(07)01290-9 [pii]
AID - 10.1016/j.bbrc.2007.06.044 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Aug 31;360(3):560-5. doi: 
      10.1016/j.bbrc.2007.06.044. Epub 2007 Jun 18.