PMID- 17618832
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20070725
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 28
IP  - 8
DP  - 2007 Aug
TI  - Dendritic cell homeostasis and trafficking in transplantation.
PG  - 353-9
AB  - Hematopoietic cell transplantation and solid organ transplantation are definitive 
      therapies for several otherwise fatal conditions. Post-transplant immune 
      reactions are the major cause of morbidity after transplantation and limit the 
      extended use of these critical therapies. Post-transplant immune complications 
      include graft rejection by the host and injury to the host mediated by the graft. 
      Dendritic cells (DCs), a population of professional antigen-presenting cells, are 
      thought to be crucial in triggering primary immune responses against both the 
      graft and the host. Here, we review studies on DC homeostasis and trafficking 
      after transplantation, and examine the role of the host and graft DC in 
      post-transplant immune responses. We also discuss the therapeutic implications of 
      these studies.
FAU - Merad, Miriam
AU  - Merad M
AD  - Department of Gene and Cell Medicine, Mount Sinai Medical School, 1425 Madison 
      Avenue, New York, NY 10029, USA. Miriam.Merad@mssm.edu
FAU - Collin, Matthew
AU  - Collin M
FAU - Bromberg, Jonathan
AU  - Bromberg J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070706
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - Dendritic Cells/*physiology
MH  - Graft vs Host Disease/etiology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Homeostasis
MH  - Humans
MH  - *Organ Transplantation
MH  - Transplantation, Homologous
RF  - 88
EDAT- 2007/07/10 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/07/10 09:00
PHST- 2007/03/30 00:00 [received]
PHST- 2007/05/22 00:00 [revised]
PHST- 2007/06/20 00:00 [accepted]
PHST- 2007/07/10 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/07/10 09:00 [entrez]
AID - S1471-4906(07)00157-3 [pii]
AID - 10.1016/j.it.2007.06.003 [doi]
PST - ppublish
SO  - Trends Immunol. 2007 Aug;28(8):353-9. doi: 10.1016/j.it.2007.06.003. Epub 2007 
      Jul 6.