PMID- 17618949
OWN - NLM
STAT- MEDLINE
DCOM- 20070823
LR  - 20240109
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 56
IP  - 8
DP  - 2007 Aug
TI  - The thermogenic and metabolic effects of protein hydrolysate with or without a 
      carbohydrate load in healthy male subjects.
PG  - 1051-9
AB  - High-protein diets are beneficial in weight maintenance because of their 
      satiating and thermogenic effects. These effects may be partly mediated by the 
      hormonal effects of proteins. This study investigated the effect of soy protein 
      hydrolysate (SPH) with and without a carbohydrate pre- and afterload on energy 
      metabolism and hormonal secretion in 8 healthy nonobese subjects. In an 
      additional trial, pea protein hydrolysate was compared to SPH, both with a 
      carbohydrate afterload. The study had a single-blind crossover design. In all 
      cases, 0.4 g protein and/or carbohydrate per kilogram of body weight was tested. 
      Diet-induced thermogenesis (DIT) was measured by ventilated hood measurements, 
      and postprandial blood samples were drawn over 3 hours. Soy protein hydrolysate 
      consumption induced a higher DIT than a carbohydrate (CHO) load. Both conditions 
      induced similar insulin responses. Soy protein hydrolysate induced a glucagon, 
      but no glucose, response; whereas CHO induced a glucose, but no glucagon, 
      response. Soy protein hydrolysate with a CHO pre- or afterload induced similar 
      DIT and insulin responses. No glucose response was found when SPH preceded the 
      CHO load. Total glucagon responses were similar with CHO as pre- and afterload, 
      but time courses were different. Pea protein hydrolysate with a CHO afterload 
      induced both higher insulin and glucagon responses (area under the curve) than 
      SPH with CHO afterload, but DIT was similar in both conditions. In conclusion, 
      this study shows that the larger DIT after protein than after CHO may be related 
      to the glucagon response that is induced by protein but not by CHO; that the 
      protein-induced DIT and glucagon response are not influenced by a CHO pre- or 
      afterload; and that protein ingestion can fully prevent the plasma glucose 
      increase associated with CHO when CHOs are ingested after proteins.
FAU - Claessens, Mandy
AU  - Claessens M
AD  - Nutrition and Toxicology Research institute Maastricht (NUTRIM), Department of 
      Human Biology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The 
      Netherlands. m.claessens@hb.unimaas.nl
FAU - Calame, Wim
AU  - Calame W
FAU - Siemensma, Andre D
AU  - Siemensma AD
FAU - Saris, Wim H M
AU  - Saris WH
FAU - van Baak, Marleen A
AU  - van Baak MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Protein Hydrolysates)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Beverages
MH  - Body Temperature Regulation/*physiology
MH  - Dietary Carbohydrates/*pharmacology
MH  - Energy Metabolism/*drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pisum sativum/chemistry
MH  - Protein Hydrolysates/*pharmacology
MH  - Glycine max/chemistry
EDAT- 2007/07/10 09:00
MHDA- 2007/08/24 09:00
CRDT- 2007/07/10 09:00
PHST- 2007/07/10 09:00 [pubmed]
PHST- 2007/08/24 09:00 [medline]
PHST- 2007/07/10 09:00 [entrez]
AID - S0026-0495(07)00122-9 [pii]
AID - 10.1016/j.metabol.2007.04.001 [doi]
PST - ppublish
SO  - Metabolism. 2007 Aug;56(8):1051-9. doi: 10.1016/j.metabol.2007.04.001.