PMID- 17619145
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20181113
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 33
IP  - 1
DP  - 2008 Jan
TI  - Intense exercise induces mitochondrial dysfunction in mice brain.
PG  - 51-8
AB  - There are conflicts between the effects of free radical over-production induced 
      by exercise on neurotrophins and brain oxidative metabolism. The objective of 
      this study was to investigate the effects of intense physical training on 
      brain-derived neurotrophic factor (BDNF) levels, COX activity, and 
      lipoperoxidation levels in mice brain cortex. Twenty-seven adult male CF1 mice 
      were assigned to three groups: control untrained, intermittent treadmill exercise 
      (3 x 15 min/day) and continuous treadmill exercise (45 min/day). Training 
      significantly (P < 0.05) increased citrate synthase activity when compared to 
      untrained control. Blood lactate levels classified the exercise as high 
      intensity. The intermittent training significantly (P < 0.05) reduced in 6.5% the 
      brain cortex COX activity when compared to the control group. BDNF levels 
      significantly (P < 0.05) decreased in both exercise groups. Besides, continuous 
      and intermittent exercise groups significantly (P < 0.05) increased 
      thiobarbituric acid reactive species levels in the brain cortex. In summary, 
      intense exercise promoted brain mitochondrial dysfunction due to decreased BDNF 
      levels in the frontal cortex of mice.
FAU - Aguiar, Aderbal S Jr
AU  - Aguiar AS Jr
AD  - Laboratory of Exercise Physiology and Biochemistry, Post-graduation Program in 
      Health Sciences, Universidade do Extremo Sul Catarinense, Criciuma, SC 88806-000, 
      Brazil.
FAU - Tuon, Talita
AU  - Tuon T
FAU - Pinho, Cleber A
AU  - Pinho CA
FAU - Silva, Luciano A
AU  - Silva LA
FAU - Andreazza, Ana C
AU  - Andreazza AC
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Quevedo, Joao
AU  - Quevedo J
FAU - Streck, Emilio L
AU  - Streck EL
FAU - Pinho, Ricardo A
AU  - Pinho RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070706
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Brain/enzymology/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Electron Transport Complex IV/metabolism
MH  - Lipid Peroxidation
MH  - Male
MH  - Mice
MH  - Mitochondria/*physiology
MH  - *Physical Conditioning, Animal
EDAT- 2007/07/10 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/07/10 09:00
PHST- 2007/01/09 00:00 [received]
PHST- 2007/06/06 00:00 [accepted]
PHST- 2007/07/10 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/07/10 09:00 [entrez]
AID - 10.1007/s11064-007-9406-x [doi]
PST - ppublish
SO  - Neurochem Res. 2008 Jan;33(1):51-8. doi: 10.1007/s11064-007-9406-x. Epub 2007 Jul 
      6.