PMID- 17620362
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20220317
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 204
IP  - 8
DP  - 2007 Aug 6
TI  - Small intestine lamina propria dendritic cells promote de novo generation of 
      Foxp3 T reg cells via retinoic acid.
PG  - 1775-85
AB  - To maintain immune homeostasis, the intestinal immune system has evolved 
      redundant regulatory strategies. In this regard, the gut is home to a large 
      number of regulatory T (T reg) cells, including the Foxp3(+) T reg cell. 
      Therefore, we hypothesized that the gut environment preferentially supports 
      extrathymic T reg cell development. We show that peripheral conversion of CD4(+) 
      T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) 
      after oral exposure to antigen and in a lymphopenic environment. Dendritic cells 
      (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were 
      found to promote a high level of T reg cell conversion relative to lymphoid 
      organ-derived DCs. This enhanced conversion by LpDCs was dependent on TGF-beta 
      and retinoic acid (RA), which is a vitamin A metabolite highly expressed in GALT. 
      Together, these data demonstrate that the intestinal immune system has evolved a 
      self-contained strategy to promote T reg cell neoconversion.
FAU - Sun, Cheng-Ming
AU  - Sun CM
AD  - Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for 
      Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 
      20892, USA.
FAU - Hall, Jason A
AU  - Hall JA
FAU - Blank, Rebecca B
AU  - Blank RB
FAU - Bouladoux, Nicolas
AU  - Bouladoux N
FAU - Oukka, Mohamed
AU  - Oukka M
FAU - Mora, J Rodrigo
AU  - Mora JR
FAU - Belkaid, Yasmine
AU  - Belkaid Y
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20070709
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
CIN - J Exp Med. 2007 Aug 6;204(8):1737-9. PMID: 17620364
MH  - Administration, Oral
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - Cell Proliferation
MH  - Dendritic Cells/cytology
MH  - Forkhead Transcription Factors/*metabolism/*physiology
MH  - Immune System
MH  - Intestine, Small/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Mucous Membrane/*metabolism
MH  - Spleen/metabolism
MH  - T-Lymphocytes, Regulatory/*metabolism
MH  - Tretinoin/*metabolism
PMC - PMC2118682
EDAT- 2007/07/11 09:00
MHDA- 2007/09/26 09:00
PMCR- 2008/02/06
CRDT- 2007/07/11 09:00
PHST- 2007/07/11 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/07/11 09:00 [entrez]
PHST- 2008/02/06 00:00 [pmc-release]
AID - jem.20070602 [pii]
AID - 20070602 [pii]
AID - 10.1084/jem.20070602 [doi]
PST - ppublish
SO  - J Exp Med. 2007 Aug 6;204(8):1775-85. doi: 10.1084/jem.20070602. Epub 2007 Jul 9.