PMID- 17621367
OWN - NLM
STAT- MEDLINE
DCOM- 20071023
LR  - 20161124
IS  - 1052-9276 (Print)
IS  - 1052-9276 (Linking)
VI  - 17
IP  - 5
DP  - 2007 Sep-Oct
TI  - Leukaemogenic mechanism of human T-cell leukaemia virus type I.
PG  - 301-11
AB  - Adult T-cell leukaemia (ATL) is a neoplastic disease derived from CD4(+) 
      T-lymphocytes and etiologically associated with human T-cell leukaemia virus type 
      I (HTLV-I). In addition to structural genes, HTLV-I encodes regulatory and 
      accessory genes in the pX region. Among them, Tax is thought to play a central 
      role in leukaemogenesis through its potent transforming activity. However, since 
      Tax is a major target of the host immune system, its expression is often lost in 
      ATL cells, indicating Tax is dispensable in the last phase of leukaemogenesis. 
      The HTLV-I bZIP factor (HBZ), encoded on the HTLV-I minus strand, was recently 
      shown to be expressed in all ATL cells, and to support growth of human T-cell 
      lines. These findings suggest that HBZ is critical to ATL onset. In addition to 
      viral factors and genetic and epigenetic changes in cellular genes, the host 
      immune status and genetic background also function in leukaemogenesis.
FAU - Yasunaga, Jun-ichirou
AU  - Yasunaga J
AD  - Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, 
      Kyoto, Japan. jyasunag@virus.kyoto-u.ac.jp
FAU - Matsuoka, Masao
AU  - Matsuoka M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Rev Med Virol
JT  - Reviews in medical virology
JID - 9112448
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (HBZ protein, human T-cell leukemia virus type I)
RN  - 0 (Retroviridae Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Basic-Leucine Zipper Transcription Factors/physiology
MH  - CD4-Positive T-Lymphocytes/*virology
MH  - *Cell Transformation, Neoplastic
MH  - Human T-lymphotropic virus 1/*physiology
MH  - Humans
MH  - Leukemia/*virology
MH  - Retroviridae Proteins
MH  - Viral Proteins/physiology
RF  - 94
EDAT- 2007/07/11 09:00
MHDA- 2007/10/24 09:00
CRDT- 2007/07/11 09:00
PHST- 2007/07/11 09:00 [pubmed]
PHST- 2007/10/24 09:00 [medline]
PHST- 2007/07/11 09:00 [entrez]
AID - 10.1002/rmv.548 [doi]
PST - ppublish
SO  - Rev Med Virol. 2007 Sep-Oct;17(5):301-11. doi: 10.1002/rmv.548.