PMID- 17623023
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20181113
IS  - 0953-816X (Print)
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 26
IP  - 2
DP  - 2007 Jul
TI  - Sexually dimorphic activation of the accessory, but not the main, olfactory bulb 
      in mice by urinary volatiles.
PG  - 463-75
AB  - Previous research suggests that volatile body odourants detected by the main 
      olfactory epithelium (MOE) are processed mainly by the main olfactory bulb (MOB) 
      whereas nonvolatile body odourants detected by the vomeronasal organ (VNO) are 
      processed via the accessory olfactory bulb (AOB). We asked whether urinary 
      volatiles from males and females differentially activate the AOB in addition to 
      the MOB in gonadectomized mice of either sex. Exposure to urinary volatiles from 
      opposite-sex but not same-sex conspecifics augmented the number of 
      Fos-immunoreactive mitral and granule cells in the AOB. Volatile urinary odours 
      from male as well as female mice also stimulated Fos expression in distinct 
      clusters of MOB glomeruli in both sexes. Intranasal administration of ZnSO(4), 
      intended to disrupt MOE function, eliminated the ability of volatile urinary 
      odours to stimulate Fos in both the MOB and AOB. In ovariectomized, 
      ZnSO(4)-treated females a significant, though attenuated, AOB Fos response 
      occurred after direct nasal exposure to male urine plus soiled bedding, 
      suggesting that VNO signaling remained partially functional in these mice. Future 
      studies will determine whether MOE or VNO signaling, or both types of input, 
      drive the sexually dimorphic response of the AOB to volatile opposite-sex odours 
      and whether this AOB response contributes to reproductive success.
FAU - Martel, Kristine L
AU  - Martel KL
AD  - Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, 
      USA.
FAU - Baum, Michael J
AU  - Baum MJ
LA  - eng
GR  - HD 59200/HD/NICHD NIH HHS/United States
GR  - R01 HD044897/HD/NICHD NIH HHS/United States
GR  - HD 044897/HD/NICHD NIH HHS/United States
GR  - R01 MH059200-03/MH/NIMH NIH HHS/United States
GR  - L50 HD059200/HD/NICHD NIH HHS/United States
GR  - R01 HD044897-04A1/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070710
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 4TI98Z838E (Estradiol)
RN  - 7733-02-0 (Zinc Sulfate)
SB  - IM
MH  - Animals
MH  - Estradiol/analogs & derivatives/pharmacology
MH  - Female
MH  - Genes, fos/genetics
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - *Odorants
MH  - Olfactory Bulb/drug effects/*physiology
MH  - Orchiectomy
MH  - Ovariectomy
MH  - Prosencephalon/physiology
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/drug effects
MH  - Urine/*chemistry
MH  - Vomeronasal Organ/physiology
MH  - Zinc Sulfate/pharmacology
PMC - PMC2258410
MID - NIHMS41034
EDAT- 2007/07/12 09:00
MHDA- 2007/10/27 09:00
PMCR- 2008/02/29
CRDT- 2007/07/12 09:00
PHST- 2007/07/12 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2007/07/12 09:00 [entrez]
PHST- 2008/02/29 00:00 [pmc-release]
AID - EJN5651 [pii]
AID - 10.1111/j.1460-9568.2007.05651.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Jul;26(2):463-75. doi: 10.1111/j.1460-9568.2007.05651.x. 
      Epub 2007 Jul 10.