PMID- 17624515
OWN - NLM
STAT- MEDLINE
DCOM- 20080107
LR  - 20220409
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 50
IP  - 9
DP  - 2007 Sep
TI  - Relationship between serum concentrations of persistent organic pollutants and 
      the prevalence of metabolic syndrome among non-diabetic adults: results from the 
      National Health and Nutrition Examination Survey 1999-2002.
PG  - 1841-1851
LID - 10.1007/s00125-007-0755-4 [doi]
AB  - AIMS/HYPOTHESIS: We recently reported associations of some persistent organic 
      pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance 
      in a US population with background exposure to POPs. Restricted to non-diabetic 
      participants, we now investigate the relationship between POPs and the metabolic 
      syndrome, a prediabetic state. MATERIALS AND METHODS: Cross-sectional 
      associations were investigated in 721 non-diabetic participants aged > or =20 
      years. Nineteen POPs in five subclasses were selected because they were 
      detectable in > or =60% of participants. RESULTS: Among five POPs subclasses, 
      organochlorine (OC) pesticides were most strongly and consistently associated 
      with metabolic syndrome: adjusted odds ratios (ORs) of 1.0, 1.5, 2.3 and 5.3 
      across OC pesticide quartiles (p for trend <0.01). Dioxin-like polychlorinated 
      biphenyls (PCBs) were also positively associated with adjusted ORs of 1.0, 1.1, 
      2.2 and 2.1 (p for trend = 0.01). However, non-dioxin-like PCBs showed an 
      inverted U-shaped association with adjusted ORs of 1.0, 1.3, 1.8 and 1.0 (p for 
      quadratic term <0.01). Associations of specific POPs varied across five 
      components of the metabolic syndrome. OC pesticides were positively and 
      significantly associated with four of the five components, especially elevated 
      triacylglycerol and high fasting glucose, but not high blood pressure. PCBs were 
      significantly associated with waist circumference, triacylglycerol and impaired 
      fasting glucose. Polychlorinated dibenzo-p-dioxins and polychlorinated 
      dibenzofurans showed small but significant associations only with high blood 
      pressure. CONCLUSIONS/INTERPRETATION: This study suggests that the prevalence of 
      a cluster of cardiovascular risk factors relates to background exposure to a 
      mixture of POPs, several of which are also related to the prevalence of diabetes. 
      POPs associated differentially with different components of the metabolic 
      syndrome.
FAU - Lee, D-H
AU  - Lee DH
AD  - Department of Preventive Medicine and Health Promotion Research Center, School of 
      Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu, 
      700-422, South Korea. lee_dh@knu.ac.kr.
FAU - Lee, I-K
AU  - Lee IK
AD  - Department of Endocrinology, School of Medicine, Kyungpook National University, 
      Daegu, South Korea.
FAU - Porta, M
AU  - Porta M
AD  - Institut Municipal d'Investigacio Medica, Universitat Autonoma de Barcelona, 
      Barcelona, Spain.
FAU - Steffes, M
AU  - Steffes M
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota, 
      Minneapolis, MN, USA.
FAU - Jacobs, D R Jr
AU  - Jacobs DR Jr
AD  - Division of Epidemiology, School of Public Health, University of Minnesota, 
      Minneapolis, MN, USA.
AD  - Department of Nutrition, University of Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20070712
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adult
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/epidemiology
MH  - Environmental Pollutants/*blood
MH  - Gas Chromatography-Mass Spectrometry
MH  - Health Surveys
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/blood/*epidemiology
MH  - Odds Ratio
MH  - Organic Chemicals/blood
MH  - Prevalence
MH  - United States
EDAT- 2007/07/13 09:00
MHDA- 2008/01/08 09:00
CRDT- 2007/07/13 09:00
PHST- 2007/01/21 00:00 [received]
PHST- 2007/06/06 00:00 [accepted]
PHST- 2007/07/13 09:00 [pubmed]
PHST- 2008/01/08 09:00 [medline]
PHST- 2007/07/13 09:00 [entrez]
AID - 10.1007/s00125-007-0755-4 [pii]
AID - 10.1007/s00125-007-0755-4 [doi]
PST - ppublish
SO  - Diabetologia. 2007 Sep;50(9):1841-1851. doi: 10.1007/s00125-007-0755-4. Epub 2007 
      Jul 12.