PMID- 17625600
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20220317
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 6
DP  - 2007 Sep
TI  - Association between RANTES functional polymorphisms and tuberculosis in Hong Kong 
      Chinese.
PG  - 475-9
AB  - Chemokines play a major role in leukocyte recruitment during the formation of 
      tuberculous granulomas. We studied the association between genetic polymorphisms 
      of three chemokines, monocyte chemoattractant protein-1 (MCP-1), RANTES 
      (regulated on activation, normal T cell expressed and secreted) and macrophage 
      inflammatory protein-1alpha (MIP-1alpha), and tuberculosis (TB). The distribution 
      of five functionally significant single-nucleotide polymorphisms (SNPs), MCP-1 
      -2518A/G, RANTES -403G/A, -28C/G and In1.1T/C as well as MIP-1alpha +459C/T was 
      not found to be different between patients with TB and healthy control subjects 
      of the Hong Kong Chinese population. However, differences in linkage 
      disequilibrium (LD) of the SNPs of RANTES and in distribution of the haplotypes 
      of RANTES between patients with TB and healthy controls (P<0.0001) were found. 
      Two risk haplotypes of RANTES, A-C-T and G-C-C, at positions -403, -28 and In1.1, 
      respectively, were identified. Furthermore, combining the genotypes of RANTES 
      -403 and In1.1, two diplotypes GA/TT (P<0.001) and GG/TC (P<0.0001) showed strong 
      association with TB. Our findings support the association between RANTES 
      functional polymorphisms and TB.
FAU - Chu, S-F
AU  - Chu SF
AD  - Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of 
      Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special 
      Administrative Region, China.
FAU - Tam, C M
AU  - Tam CM
FAU - Wong, H S
AU  - Wong HS
FAU - Kam, K M
AU  - Kam KM
FAU - Lau, Y L
AU  - Lau YL
FAU - Chiang, A K S
AU  - Chiang AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070712
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/genetics
MH  - Chemokine CCL5/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Hong Kong
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Macrophage Inflammatory Proteins/genetics
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis
MH  - *Polymorphism, Single Nucleotide
MH  - Tuberculosis/*genetics
EDAT- 2007/07/13 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/13 09:00
PHST- 2007/07/13 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/13 09:00 [entrez]
AID - 6364412 [pii]
AID - 10.1038/sj.gene.6364412 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Sep;8(6):475-9. doi: 10.1038/sj.gene.6364412. Epub 2007 Jul 12.