PMID- 17627748
OWN - NLM
STAT- MEDLINE
DCOM- 20071019
LR  - 20171116
IS  - 1743-6095 (Print)
IS  - 1743-6095 (Linking)
VI  - 4
IP  - 4 Pt 1
DP  - 2007 Jul
TI  - NCEP-ATPIII-defined metabolic syndrome, type 2 diabetes mellitus, and prevalence 
      of hypogonadism in male patients with sexual dysfunction.
PG  - 1038-45
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are 
      characterized by insulin resistance and often associated with male hypogonadism. 
      AIM: To discriminate the specific contribution of T2DM and MetS to male 
      hypogonadism. METHODS: A consecutive series of 1,134 (mean age 52.1 +/- 13 years) 
      male patients with sexual dysfunction was studied. MAIN OUTCOME MEASURES: Several 
      hormonal and biochemical parameters were studied along with ANDROTEST, a 12-item 
      validated structured interview, specifically designed for the screening of 
      hypogonadism (total testosterone [TT] <10.4 nmol/L or free testosterone [FT] <37 
      pmol/L) in a male population with sexual dysfunction. RESULTS: Irrespective of 
      the criteria used to define hypogonadism, MetS was associated with a 
      significantly higher prevalence of the condition, both in subjects with and 
      without T2DM (41% and 29% vs. 13.2% and 77.1% and 58% vs. 40.6%, respectively, 
      for TT and FT in patients with MetS and with or without T2DM, when compared with 
      subjects without MetS and T2DM; both P < 0.0001). Conversely, T2DM was associated 
      with a higher prevalence of hypogonadism in subjects with MetS but not in those 
      without MetS. Patients with MetS, with or without T2DM, also showed a higher 
      ANDROTEST score when compared with patients without MetS. Logistic multivariate 
      regression analysis, incorporating the five components of MetS, identified a 
      significant association of elevated waist circumference and hypertriglyceridemia 
      with hypogonadism both in patients, with or without T2DM. CONCLUSIONS: Our study 
      demonstrated that MetS, and in particular visceral adiposity (as assessed by 
      increased waistline and hypertriglyceridemia), is specifically associated with 
      hypogonadism in subjects consulting for sexual dysfunction.
FAU - Corona, Giovanni
AU  - Corona G
AD  - Andrology Unit, Department of Clinical Physiopathology, University of Florence, 
      Fiale Pieraccini 6, 50139 Florence, Italy.
FAU - Mannucci, Edoardo
AU  - Mannucci E
FAU - Petrone, Luisa
AU  - Petrone L
FAU - Balercia, Giancarlo
AU  - Balercia G
FAU - Paggi, Francesca
AU  - Paggi F
FAU - Fisher, Alessandra D
AU  - Fisher AD
FAU - Lotti, Francesco
AU  - Lotti F
FAU - Chiarini, Valerio
AU  - Chiarini V
FAU - Fedele, Domenico
AU  - Fedele D
FAU - Forti, Gianni
AU  - Forti G
FAU - Maggi, Mario
AU  - Maggi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*classification/*diagnosis/epidemiology
MH  - Humans
MH  - Hypogonadism/*classification/*epidemiology
MH  - Impotence, Vasculogenic/*epidemiology/etiology
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/*classification/*diagnosis/epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2007/07/14 09:00
MHDA- 2007/10/20 09:00
CRDT- 2007/07/14 09:00
PHST- 2007/07/14 09:00 [pubmed]
PHST- 2007/10/20 09:00 [medline]
PHST- 2007/07/14 09:00 [entrez]
AID - S1743-6095(15)31602-7 [pii]
AID - 10.1111/j.1743-6109.2007.00529.x [doi]
PST - ppublish
SO  - J Sex Med. 2007 Jul;4(4 Pt 1):1038-45. doi: 10.1111/j.1743-6109.2007.00529.x.