PMID- 17627758
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20070713
IS  - 1744-3121 (Print)
IS  - 1744-3121 (Linking)
VI  - 34
IP  - 4
DP  - 2007 Aug
TI  - HLA-A2 class I antigens in couples with recurrent spontaneous abortions.
PG  - 241-6
AB  - Class I human leukocyte antigen (HLA) antigens, locus A and B, were typed in 
      fertile and infertile couples in cases where one of the spouses carried the 
      HLA-A2 antigen. HLA-class I typing data were obtained from 282 participants, 63 
      fertile couples and 78 infertile couples with recurrent spontaneous abortions 
      (RSA). Locus A antigens were grouped into eight broad specificities (A1, A2, A3, 
      A9, A10, A11, A19, A28) and locus B antigens were grouped, according to HLA 
      epitopes, in two classes (BW4 and BW6). Although the number of cases is small, 
      significant differences in the distribution of locus A antigens were found 
      between HLA-A2-positive (A2+) women from fertile and infertile couples. HLA-A3, 
      A11 and A28 cross-reacting antigens were absent in women from fertile couples and 
      present in women from infertile couples. HLA-A19, which is associated with amino 
      acid triplets of low immunogenicity, was significantly more often observed in A2+ 
      fertile than in infertile women. An excess of the BW4 epitope was found in A2(-) 
      husbands from infertile couples compared to fertile ones. The results of this 
      study support the idea that in the presence of the HLA-A2 molecule the 
      distribution of HLA-A and B loci antigens may be different in fertile couples 
      compared to couples with recurrent spontaneous abortions. It can be suggested 
      that the HLA-A2 molecule, in context with specific genotypes, may contribute to 
      the overall maternal immune response in normal and disturbed pregnancy.
FAU - Komlos, L
AU  - Komlos L
AD  - Golda Medical Center, Petach-Tiqwa, Israel.
FAU - Klein, T
AU  - Klein T
FAU - Korostishevsky, M
AU  - Korostishevsky M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Adult
MH  - Female
MH  - HLA-A2 Antigen/*analysis/*genetics
MH  - Humans
MH  - Lymphocytes/*immunology
MH  - Male
MH  - Pregnancy
EDAT- 2007/07/14 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/07/14 09:00
PHST- 2007/07/14 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/07/14 09:00 [entrez]
AID - EJI682 [pii]
AID - 10.1111/j.1744-313X.2007.00682.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2007 Aug;34(4):241-6. doi: 10.1111/j.1744-313X.2007.00682.x.