PMID- 17627803
OWN - NLM
STAT- MEDLINE
DCOM- 20071128
LR  - 20070926
IS  - 0268-9146 (Print)
IS  - 0268-9146 (Linking)
VI  - 38
IP  - 5
DP  - 2007 Oct
TI  - Quantitative trait loci for red blood cell traits in swine.
PG  - 447-52
AB  - Haematological traits are essential diagnostic parameters in veterinary practice 
      but knowledge on the genetic architecture controlling variability of erythroid 
      traits is sparse, especially in swine. To identify QTL for erythroid traits in 
      the pig, haematocrit (HCT), haemoglobin (HB), erythrocyte counts (RBC) and mean 
      corpuscular haemoglobin content (MCHC) were measured in 139 F(2) pigs from a 
      Meishan/Pietrain family, before and after challenge with the protozoan pathogen 
      Sarcocystis miescheriana. The pigs passed through three stages representing acute 
      disease, reconvalescence and chronic disease. Forty-three single QTL controlling 
      erythroid traits were identified on 16 chromosomes. Twelve of the QTL were 
      significant at the genome-wide level while 31 were significant at a 
      chromosome-wide level. Because erythroid traits varied with health and disease 
      status, QTL influencing the erythroid phenotypes showed specific health/disease 
      patterns. Regions on SSC5, 7, 8, 12 and 13 contained QTL for baseline erythroid 
      traits, while the other QTL regions affected distinct stages of the disease 
      model. Single QTL explained 9-17% of the phenotypic variance in the F(2) animals. 
      Related traits were partly under common genetic influence. Our analysis confirms 
      that erythroid trait variation differs between Meishan and Pietrain breeds and 
      that this variation is associated with multiple chromosomal regions.
FAU - Reiner, G
AU  - Reiner G
AD  - Department of Veterinary Clinical Sciences, University of Giessen, D-35392 
      Giessen, Germany. gerald.reiner@vetmed.uni-giessen.de
FAU - Fischer, R
AU  - Fischer R
FAU - Hepp, S
AU  - Hepp S
FAU - Berge, T
AU  - Berge T
FAU - Kohler, F
AU  - Kohler F
FAU - Willems, H
AU  - Willems H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070713
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - Erythrocytes/*cytology/*metabolism
MH  - Female
MH  - Male
MH  - Quantitative Trait Loci/*genetics
MH  - Swine/*blood/*genetics
EDAT- 2007/07/14 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/07/14 09:00
PHST- 2007/07/14 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/07/14 09:00 [entrez]
AID - AGE1629 [pii]
AID - 10.1111/j.1365-2052.2007.01629.x [doi]
PST - ppublish
SO  - Anim Genet. 2007 Oct;38(5):447-52. doi: 10.1111/j.1365-2052.2007.01629.x. Epub 
      2007 Jul 13.