PMID- 17628454
OWN - NLM
STAT- MEDLINE
DCOM- 20080109
LR  - 20141120
IS  - 0928-4257 (Print)
IS  - 0928-4257 (Linking)
VI  - 100
IP  - 5-6
DP  - 2006 Nov-Dec
TI  - Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory 
      neural network activity in mice in vitro.
PG  - 290-6
AB  - In humans, several pathologies are associated with disturbances of the 
      respiratory control, some of them including alteration in the brain-derived 
      neurotrophic factor (BDNF) signalling pathway. BDNF has long been known as a 
      neurotrophic factor involved in survival, differentiation and maintenance of 
      neuronal populations in the peripheral and central nervous system. More recently 
      BDNF has also been discovered to be a potent neuromodulator with acute effects on 
      neuronal excitability and synaptic plasticity. Animals deleted for the gene 
      encoding BDNF exhibit respiratory alteration suggesting an important but yet 
      undefined role of the neurotrophin in respiratory rhythmogenesis either by a 
      trophic and/or an acute action. The possibility that BDNF might exert an acute 
      regulatory role on the rhythmic activity of the respiratory generator of the 
      pre-Botzinger complex has been recently examined in newborn mice in vitro. 
      Results obtained, reviewed in the present paper, will help getting insights in 
      respiratory rhythm regulatory mechanisms that involve BDNF signalling.
FAU - Bouvier, Julien
AU  - Bouvier J
AD  - Laboratoire de Neurobiologie Genetique et Integrative Institut Alfred Fessard, 
      CNRS UPR2216, 1 avenue de la terrasse, 91198 Gif sur Yvette, France.
FAU - Autran, Sandra
AU  - Autran S
FAU - Fortin, Gilles
AU  - Fortin G
FAU - Champagnat, Jean
AU  - Champagnat J
FAU - Thoby-Brisson, Muriel
AU  - Thoby-Brisson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070608
PL  - France
TA  - J Physiol Paris
JT  - Journal of physiology, Paris
JID - 9309351
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Humans
MH  - In Vitro Techniques
MH  - Mice
MH  - Nerve Net/*physiology
MH  - Neurons/physiology
MH  - *Periodicity
MH  - Respiratory Center/anatomy & histology/*physiology
MH  - Signal Transduction/physiology
RF  - 82
EDAT- 2007/07/14 09:00
MHDA- 2008/01/10 09:00
CRDT- 2007/07/14 09:00
PHST- 2007/07/14 09:00 [pubmed]
PHST- 2008/01/10 09:00 [medline]
PHST- 2007/07/14 09:00 [entrez]
AID - S0928-4257(07)00019-8 [pii]
AID - 10.1016/j.jphysparis.2007.05.008 [doi]
PST - ppublish
SO  - J Physiol Paris. 2006 Nov-Dec;100(5-6):290-6. doi: 
      10.1016/j.jphysparis.2007.05.008. Epub 2007 Jun 8.