PMID- 17629003
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20070716
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 42
IP  - 5
DP  - 2007 May
TI  - [Expression difference of toll-like receptors among chronic rhinosinusitis and 
      nasal polyps].
PG  - 345-9
AB  - OBJECTIVE: To compare the expression difference of Toll-like receptor-2 (TLR-2) 
      and Toll-like receptor-4 (TLR-4) protein and mRNA among the chronic 
      rhinosinusitis tissues, nasal polyps tissues, and normal mucosa tissues. METHODS: 
      The mRNA expression of TLR-2 and TLR-4 in chronic rhinosinusitis tissues from 10 
      patients, in nasal polyp tissues from 10 patients, and in inferior turbinate 
      tissues from 10 patients underwent nasal septum operation was detected by means 
      of reverse transcriptase-polymerase chain reaction (RT-PCR). Immunohistochemistry 
      (IHC) was used to detected the expression of TLR-2 and TLR-4 protein in a 
      different set of 20 chronic rhinosinusitis tissues, 20 nasal polyp tissues, and 
      20 normal inferior turbinate tissues. RESULTS: (1) The mRNA and protein 
      expression of TLR-2 and TLR-4 was detected on epithelial and glandular cells 
      membrane in all chronic rhinosinusitis, nasal polyps and control tissues . (2) 
      The mRNA and protein expression of TLR-2 and the mRNA expression of TLR-4 in 
      chronic rhinosinusitis tissues was significantly increased compared with that in 
      nasal polyps and control tissues (P < 0.05). (3) The expression intensity of 
      TLR-2 and TLR-4 mRNA and protein between nasal polyps and control tissues was 
      found no significant difference (P > 0.05). CONCLUSIONS: Different TLR-2 and 
      TLR-4 protein and mRNA level in chronic rhinosinusitis and nasal polyp tissues 
      might imply that TLR-2 and TLR-4 play different role in the pathogenesis of 
      chronic rhinosinusitis and nasal polyps.
FAU - You, Xue-Jun
AU  - You XJ
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Tongfi Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan 430030, 
      China. drxjyou@yahoo.com.cn
FAU - Lu, Xiang
AU  - Lu X
FAU - Liu, Yang
AU  - Liu Y
FAU - Liu, Zheng
AU  - Liu Z
FAU - Gao, Qi-Xue
AU  - Gao QX
FAU - Cui, Yonghua
AU  - Cui Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (RNA, Messenger)
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/metabolism
MH  - Nasal Polyps/*metabolism
MH  - RNA, Messenger/genetics
MH  - Sinusitis/*metabolism
MH  - Toll-Like Receptor 2/genetics/*metabolism
MH  - Toll-Like Receptor 4/genetics/*metabolism
MH  - Young Adult
EDAT- 2007/07/17 09:00
MHDA- 2011/09/09 06:00
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 May;42(5):345-9.