PMID- 17629636
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20071123
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 126
IP  - 1-3
DP  - 2008 Jan 1
TI  - Experimental study of pathogenicity of Pasteurella multocida serogroup F in 
      rabbits.
PG  - 168-77
AB  - The role of Pasteurella multocida serogroup F in inducing disease in rabbits was 
      investigated in this study. Three groups of 12 Pasteurella-free rabbits each were 
      intranasally (i.n.), subcutaneously (s.c.), and perorally (p.o.) challenged, 
      respectively. Six rabbits of each group were immunosuppressed using 
      dexamethasone. Eight rabbits (four of them immunosuppressed) inoculated i.n. 
      showed symptoms of respiratory distress resulting in respiratory failure and died 
      or were euthanized in the terminal stage of the disease 3-6 days post-infection 
      (p.i.). The main pathological findings were fibrinopurulent pleuropneumonia 
      (immunocompetent rabbits) or diffuse haemorrhagic pneumonia (immunosuppressed 
      rabbits). Septicemic syndrome ending with shock occurred in 11 rabbits (6 of them 
      immunosuppressed) inoculated s.c., which died or were euthanized in the terminal 
      stage of the disease 2-3 days p.i. The most significant pathological findings 
      were extensive cutaneous and subcutaneous lesions. All of the p.o. inoculated 
      rabbits survived the challenge showing no clinical signs of the disease and no 
      macroscopic lesions. The observations in this study indicate that in addition to 
      serogroups A and D of P. multocida, serogroup F also can be highly pathogenic for 
      rabbits and therefore might be a cause of considerable economic loss in 
      commercial rabbit production.
FAU - Jaglic, Zoran
AU  - Jaglic Z
AD  - Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic. 
      jaglic@vri.cz
FAU - Jeklova, Edita
AU  - Jeklova E
FAU - Leva, Lenka
AU  - Leva L
FAU - Kummer, Vladimir
AU  - Kummer V
FAU - Kucerova, Zdenka
AU  - Kucerova Z
FAU - Faldyna, Martin
AU  - Faldyna M
FAU - Maskova, Jarmila
AU  - Maskova J
FAU - Nedbalcova, Katerina
AU  - Nedbalcova K
FAU - Alexa, Pavel
AU  - Alexa P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070617
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Female
MH  - Immunocompromised Host
MH  - Lung/microbiology/pathology
MH  - Male
MH  - Pasteurella Infections/microbiology/pathology/*veterinary
MH  - Pasteurella multocida/*classification/*pathogenicity
MH  - Rabbits
MH  - Specific Pathogen-Free Organisms
MH  - Subcutaneous Tissue/microbiology/pathology
MH  - Virulence
EDAT- 2007/07/17 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/07/17 09:00
PHST- 2007/03/29 00:00 [received]
PHST- 2007/05/28 00:00 [revised]
PHST- 2007/06/04 00:00 [accepted]
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - S0378-1135(07)00301-X [pii]
AID - 10.1016/j.vetmic.2007.06.008 [doi]
PST - ppublish
SO  - Vet Microbiol. 2008 Jan 1;126(1-3):168-77. doi: 10.1016/j.vetmic.2007.06.008. 
      Epub 2007 Jun 17.