PMID- 17630209
OWN - NLM
STAT- MEDLINE
DCOM- 20071029
LR  - 20070724
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 422
IP  - 2
DP  - 2007 Jul 11
TI  - Effect of mild hypothermia on angiogenesis in rats with focal cerebral ischemia.
PG  - 87-90
AB  - In the present study, we investigated the effect of mild hypothermia on infarct 
      volume, angiogenesis and brain-derived neurotrophic factor (BDNF) level after 
      stroke. After permanent middle cerebral artery occlusion, mild hypothermia was 
      induced immediately and maintained for 24h. 2,3,5-Triphenyltetrazolium chloride 
      (TTC) staining, laser scanning confocal microscopy (LSCM) and ELISA were 
      performed to assay infarct volume, angiogenesis and BDNF level in the ischemic 
      boundary zone (IBZ), respectively. Compared with normothermic group, mild 
      hypothermia reduced total infarct volume and increased endogenous BDNF level. And 
      the microvessel diameter, the number of vascular branch points and the vessel 
      surface area were significantly increased in the mild hypothermia group. These 
      findings suggest that mild hypothermia enhances angiogenesis in ischemic brain, 
      which might be enhanced in part via BDNF.
FAU - Xie, Yan-Chun
AU  - Xie YC
AD  - Department of Neurology, Institution of Neuropsychiatry Research, Renmin Hospital 
      of Wuhan University, Jiefang Road 238, Wuhan 430060, Hubei, PR China.
FAU - Li, Cheng-Yan
AU  - Li CY
FAU - Li, Tao
AU  - Li T
FAU - Nie, De-Yun
AU  - Nie DY
FAU - Ye, Fei
AU  - Ye F
LA  - eng
PT  - Journal Article
DEP - 20070419
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tetrazolium Salts)
SB  - IM
MH  - Animals
MH  - Brain/blood supply/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Arteries/pathology
MH  - Cerebral Infarction/pathology/physiopathology/*therapy
MH  - Disease Models, Animal
MH  - Hypothermia, Induced/*methods
MH  - Hypoxia-Ischemia, Brain/pathology/physiopathology/*therapy
MH  - Infarction, Middle Cerebral Artery/pathology/physiopathology/therapy
MH  - Male
MH  - Microcirculation/pathology
MH  - Microscopy, Confocal
MH  - *Neovascularization, Physiologic
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tetrazolium Salts
MH  - Treatment Outcome
MH  - Up-Regulation
EDAT- 2007/07/17 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/07/17 09:00
PHST- 2006/12/22 00:00 [received]
PHST- 2007/03/09 00:00 [revised]
PHST- 2007/03/30 00:00 [accepted]
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - S0304-3940(07)00395-3 [pii]
AID - 10.1016/j.neulet.2007.03.072 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Jul 11;422(2):87-90. doi: 10.1016/j.neulet.2007.03.072. Epub 
      2007 Apr 19.