PMID- 17631008
OWN - NLM
STAT- MEDLINE
DCOM- 20070919
LR  - 20070716
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 58
IP  - 2
DP  - 2007 Aug
TI  - Antiphospholipid antibodies: effects on trophoblast and endothelial cells.
PG  - 150-8
AB  - PROBLEM: Antiphospholipid syndrome (APS) may affect placental functions through 
      several possible mechanisms. Interaction of antiphospholipid antibodies (aPL) 
      with cells involved in the coagulation cascade is thought to produce a 
      procoagulant state. Thrombotic placental pathology is however not specific for 
      the APS. METHOD OF STUDY: An analysis of published data. RESULTS: It is now 
      generally accepted that the clinically relevant aPL bind to proteins with 
      affinity for phospholipids (PL), such as beta2-glycoprotein I (beta2-GPI). 
      Following the attachment of beta2-GPI to trophoblast anionic PL, both molecules 
      undergo conformational changes resulting in the exposure of cryptic epitopes 
      within the structure of beta2-GPI. This may allow the subsequent binding of 
      antibodies hence affecting trophoblast functions directly. Moreover 
      anti-beta2-GPI antibodies induce the activation of endothelial cells (ECs), 
      resulting in a proinflammatory state which favours the prothrombotic diathesis of 
      the syndrome. CONCLUSION: Numerous ameliorations in the APS knowledge have been 
      introduced in the last few years. To have clarified the mechanism of antibody 
      mediated damage on trophoblast and ECs represents an important step to explain 
      the cellular events leading to pregnancy complications.
FAU - D'Ippolito, Silvia
AU  - D'Ippolito S
AD  - Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, 
      Rome, Italy.
FAU - Di Simone, Nicoletta
AU  - Di Simone N
FAU - Di Nicuolo, Fiorella
AU  - Di Nicuolo F
FAU - Castellani, Roberta
AU  - Castellani R
FAU - Caruso, Alessandro
AU  - Caruso A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Animals
MH  - Antibodies, Antiphospholipid/*physiology
MH  - Antiphospholipid Syndrome/*immunology/pathology
MH  - Endothelium/cytology/*immunology
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Trophoblasts/cytology/*immunology
RF  - 78
EDAT- 2007/07/17 09:00
MHDA- 2007/09/20 09:00
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2007/09/20 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - AJI500 [pii]
AID - 10.1111/j.1600-0897.2007.00500.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2007 Aug;58(2):150-8. doi: 10.1111/j.1600-0897.2007.00500.x.