PMID- 17631515
OWN - NLM
STAT- MEDLINE
DCOM- 20080114
LR  - 20070830
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 9
IP  - 9
DP  - 2007 Sep
TI  - Triple-site biventricular pacing in patients undergoing cardiac resynchronization 
      therapy: a feasibility study.
PG  - 762-7
AB  - AIMS: To evaluate implantation safety and efficiency of triple-site (double 
      left-single right) cardiac resynchronization therapy (CRT) and to assess the 
      outcome of this procedure. METHODS AND RESULTS: Twenty-six patients with New York 
      Heart Association (NYHA) class III-IV, left ventricular ejection fraction (EF) < 
      or = 35%, and QRS > or = 120 ms underwent triple-site CRT. Procedural course and 
      complications were analysed. NYHA class, QRS duration, echocardiographic 
      parameters, peak oxygen consumption (VO(2)max), and 6 min walking distance (6MWD) 
      were assessed at baseline and after 3 months. Responders were defined by 
      survival, by no re-hospitalization for heart failure, and by >10% EF, VO(2)max, 
      and 6MWD increase. Implantation was successful in 22 patients (84.6%). Procedure 
      duration (199.1 min) and fluoroscopy time (38.7 min) were higher than in standard 
      procedures. Two clinically silent coronary sinus dissections occurred 
      intra-operatively; one phrenic nerve stimulation and one pocket infection were 
      observed during follow-up. After 3 months of CRT, a significant reduction (P < 
      0.05) of NYHA class, increment of VO(2)max, 6MWD, EF, and improvement of indices 
      of dyssynchrony were observed. Response rate in the studied group was 95.4%. 
      CONCLUSION: Triple-site resynchronization appears to be a safe and efficient 
      treatment method, with high response rate. Further studies are needed to evaluate 
      the role of this pacing mode in CRT.
FAU - Lenarczyk, Radoslaw
AU  - Lenarczyk R
AD  - First Department of Cardiology, Silesian Center for Heart Disease, Silesian 
      Medical School, ul Szpitalna 2, 41-800, Zabrze, Poland. elfizab@poczta.onet.pl
FAU - Kowalski, Oskar
AU  - Kowalski O
FAU - Kukulski, Tomasz
AU  - Kukulski T
FAU - Szulik, Mariola
AU  - Szulik M
FAU - Pruszkowska-Skrzep, Patrycja
AU  - Pruszkowska-Skrzep P
FAU - Zielinska, Teresa
AU  - Zielinska T
FAU - Kowalczyk, Jacek
AU  - Kowalczyk J
FAU - Pluta, Slawomir
AU  - Pluta S
FAU - Duszanska, Agata
AU  - Duszanska A
FAU - Sredniawa, Beata
AU  - Sredniawa B
FAU - Musialik-Lydka, Agata
AU  - Musialik-Lydka A
FAU - Kalarus, Zbigniew
AU  - Kalarus Z
LA  - eng
PT  - Journal Article
DEP - 20070713
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Aged
MH  - Binding Sites
MH  - Cardiac Pacing, Artificial/*methods
MH  - Echocardiography/methods
MH  - Electrocardiography/methods
MH  - Female
MH  - Heart Failure/pathology/*therapy
MH  - *Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - Pacemaker, Artificial
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2007/07/17 09:00
MHDA- 2008/01/15 09:00
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2008/01/15 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - eum140 [pii]
AID - 10.1093/europace/eum140 [doi]
PST - ppublish
SO  - Europace. 2007 Sep;9(9):762-7. doi: 10.1093/europace/eum140. Epub 2007 Jul 13.