PMID- 17631731
OWN - NLM
STAT- MEDLINE
DCOM- 20070830
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 25
IP  - 3
DP  - 2007 May-Jun
TI  - Results of the Health Assessment Questionnaire for Japanese patients with 
      systemic sclerosis--measuring functional impairment in systemic sclerosis versus 
      other connective tissue diseases.
PG  - 367-72
AB  - OBJECTIVE: To evaluate the physical functional impairment in patients with 
      systemic sclerosis (SSc) using the Health Assessment Questionnaire (HAQ) and to 
      estimate the correlation of HAQ scores with the severity of SSc. METHODS: One 
      hundred and twenty-four outpatients with connective tissue disease, including 50 
      patients with SSc, were evaluated using the HAQ. Twelve patients were classified 
      as having diffuse cutaneous SSc (dSSc) and 38 limited cutaneous SSc (lSSc). The 
      severity classification and the guidelines for treatment (2004) were applied to 
      Japanese SSc patients in order to evaluate the relationship between HAQ scores 
      and disease activity in patients with multiple organ involvement. RESULTS: In 
      dSSc the HAQ category scores for eating, walking, grip, activity and the 
      HAQ-disability index (HAQ-DI) showed the greatest deficits in all disease groups. 
      The severity of disease activity correlated significantly with the scores for 
      walking, reach, and the HAQ-DI. The severity of joint, heart, and pulmonary 
      hypertension were correlated independently with the HAQ-DI score by multiple 
      linear regression analysis. CONCLUSION: Patients with dSSc suffer greater 
      functional impairment than patients with other connective tissue diseases, and 
      improvements in hand use and walking represent very important targets for both 
      drug development and rehabilitation. As improvement in organ involvement (joints, 
      heart as well as pulmonary hypertension) can lead to reduced functional 
      impairment, they constitute an important target for therapy in SSc.
FAU - Morita, Y
AU  - Morita Y
AD  - Division of Connective Tissue Disease & Autoimmunity, Department of Dermatology 
      of Public Health/Health Information Dynamics, Nagoya University Graduate School 
      of Medicine, Nagoya, Japan.
FAU - Muro, Y
AU  - Muro Y
FAU - Sugiura, K
AU  - Sugiura K
FAU - Tomita, Y
AU  - Tomita Y
FAU - Tamakoshi, K
AU  - Tamakoshi K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Connective Tissue Diseases/classification/ethnology/*physiopathology
MH  - Disability Evaluation
MH  - Female
MH  - Hand Strength/physiology
MH  - *Health Surveys
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Scleroderma, Systemic/classification/ethnology/*physiopathology
MH  - Severity of Illness Index
MH  - Skin Diseases/classification/ethnology/physiopathology
MH  - Walking/physiology
EDAT- 2007/07/17 09:00
MHDA- 2007/08/31 09:00
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2007/08/31 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - 2062 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2007 May-Jun;25(3):367-72.