PMID- 17631804
OWN - NLM
STAT- MEDLINE
DCOM- 20091204
LR  - 20070716
IS  - 1672-1977 (Print)
IS  - 1672-1977 (Linking)
VI  - 5
IP  - 4
DP  - 2007 Jul
TI  - [Effects of Huanglian Jiedu Decoction on glucose transporter 4 in target tissues 
      of type 2 diabetic rats].
PG  - 412-5
AB  - OBJECTIVE: To investigate the molecular mechanism of Huanglian Jiedu Decoction 
      (HLJDD), a traditional Chinese compound herbal medicine, in treating type 2 
      diabetes mellitus (T2DM) by observing its effects on glucose transporter 4 
      (GLUT4) protein expression and translocation in adipose and skeletal muscle 
      tissues of rats with T2DM. METHODS: T2DM was induced in rats by intravenous 
      injection of a small dose of streptozotocin (STZ, 30 mg/kg) plus high fat and 
      high caloric laboratory chow. Then animals were divided into untreated group, 
      aspirin-treated group and HLJDD-treated group. Normal rats fed with common chow 
      were designated as normal control group. Ten weeks later, the oral glucose 
      tolerance test (OGTT) was performed in all animals, and the changes of murine 
      body weight, fasting blood glucose (FBG), fasting serum insulin (FINS) and the 
      expression of GLUT4 protein in skeletal muscle and adipose tissues before and 
      after insulin treatment were routinely determined. RESULTS: Compared with the 
      untreated group, the result of OGTT of HLJDD-treated group was improved. The 
      levels of the body weight and FBG were decreased, while the GLUT4 protein 
      expression and translocation were elevated obviously. CONCLUSION: It is suggested 
      by the present results that the therapeutic effects of HLJDD on T2DM might be 
      related to its ability of increasing GLUT4 protein expression and translocation 
      in adipose and skeletal muscle tissues of T2DM rats.
FAU - Chen, Guang
AU  - Chen G
AD  - Institute of Integrated Traditional & Western Medicine, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 
      Province 430030, China.
FAU - Lu, Fu-er
AU  - Lu FE
FAU - Xu, Li-jun
AU  - Xu LJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Xi Yi Jie He Xue Bao
JT  - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
JID - 101199657
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Slc2a4 protein, rat)
RN  - 0 (oren gedoku to)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Diabetes Mellitus, Experimental/drug therapy
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Glucose Transporter Type 4/drug effects/*metabolism
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - *Phytotherapy
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
EDAT- 2007/07/17 09:00
MHDA- 2009/12/16 06:00
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
AID - 167219772007040412 [pii]
PST - ppublish
SO  - Zhong Xi Yi Jie He Xue Bao. 2007 Jul;5(4):412-5.