PMID- 17632285
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20191008
IS  - 0959-4965 (Print)
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 18
IP  - 12
DP  - 2007 Aug 6
TI  - The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and 
      depression in Mexican-Americans.
PG  - 1291-3
AB  - The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the 
      pathogenesis of major depression is supported by several research findings; 
      however, genetic studies assessing the relationship between BDNF and psychiatric 
      disorders have produced conflicting results. We examined the effect of a BDNF 
      polymorphism on depression susceptibility in Mexican-Americans. The single 
      nucleotide polymorphism (Val66Met), which has been shown to have functional and 
      behavioral effects, was genotyped in 284 depressed participants and 331 controls, 
      showing association with depression (P=0.005). Individuals homozygous for the 
      major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 
      1.17-2.47). Our findings support the association of BDNF single nucleotide 
      polymorphism rs6265 and depression, suggesting that this polymorphism may 
      increase susceptibility to major depression in Mexican-Americans.
FAU - Ribeiro, Luciana
AU  - Ribeiro L
AD  - Department of Psychiatry & Behavioral Sciences, Center on Pharmacogenomics, 
      University of Miami Miller School of Medicine, Miami, Florida 33136-1013, USA. 
      lribeiro@med.miami.edu
FAU - Busnello, Joao V
AU  - Busnello JV
FAU - Cantor, Rita M
AU  - Cantor RM
FAU - Whelan, Fiona
AU  - Whelan F
FAU - Whittaker, Pamela
AU  - Whittaker P
FAU - Deloukas, Panos
AU  - Deloukas P
FAU - Wong, Ma-Li
AU  - Wong ML
FAU - Licinio, Julio
AU  - Licinio J
LA  - eng
GR  - HG002500/HG/NHGRI NIH HHS/United States
GR  - RR000865/RR/NCRR NIH HHS/United States
GR  - R01 DK063240/DK/NIDDK NIH HHS/United States
GR  - M01 RR000865/RR/NCRR NIH HHS/United States
GR  - MH062777/MH/NIMH NIH HHS/United States
GR  - DK063240/DK/NIDDK NIH HHS/United States
GR  - 077011/Wellcome Trust/United Kingdom
GR  - RR017365/RR/NCRR NIH HHS/United States
GR  - R03 HG002500/HG/NHGRI NIH HHS/United States
GR  - U01 GM061394/GM/NIGMS NIH HHS/United States
GR  - K24 RR016996/RR/NCRR NIH HHS/United States
GR  - GM61394/GM/NIGMS NIH HHS/United States
GR  - K24 RR017365/RR/NCRR NIH HHS/United States
GR  - RR16996/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution/genetics
MH  - Brain/metabolism/physiopathology
MH  - Brain Chemistry/*genetics
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - DNA Mutational Analysis
MH  - Depressive Disorder/*ethnology/*genetics/metabolism
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Mexican Americans/ethnology/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Valine/genetics
PMC - PMC2686836
MID - UKMS4593
OID - NLM: UKMS4593
EDAT- 2007/07/17 09:00
MHDA- 2007/09/28 09:00
PMCR- 2009/05/27
CRDT- 2007/07/17 09:00
PHST- 2007/07/17 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/07/17 09:00 [entrez]
PHST- 2009/05/27 00:00 [pmc-release]
AID - 00001756-200708060-00018 [pii]
AID - 10.1097/WNR.0b013e328273bcb0 [doi]
PST - ppublish
SO  - Neuroreport. 2007 Aug 6;18(12):1291-3. doi: 10.1097/WNR.0b013e328273bcb0.