PMID- 17634026
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20181201
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 21
IP  - 9
DP  - 2007 May
TI  - [Expression and role of survivin in laryngeal squamous cell carcinoma and 
      laryngeal papilloma in adults].
PG  - 413-6
AB  - OBJECTIVE: To study the expression of Survivin in laryngeal squamous cell 
      carcinoma (LSCC) and laryngeal papilloma in adults and its significance in 
      carcinogenesis and development of the LSCC. METHOD: The expressions of Survivin 
      protein were detected by immunohistochemistry technique in 46 cases of LSCC, 24 
      cases of adjacent nontumorous laryngeal epithelium, 20 cases of laryngeal 
      papilloma and 16 cases of normal laryngeal epithelium. RESULT: The positive rates 
      of Survivin protein expression in laryngeal carcinoma, adjacent nontumorous 
      laryngeal epithelium and laryngeal papilloma were 71.74% (33/46), 33.33% 
      (8/24)and 40.00% (8/20) respectively. There was no expression in normal laryngeal 
      epithelium. The positive rate of Survivin protein expression in laryngeal 
      carcinoma was significantly higher than that in the adjacent nontumorous 
      laryngeal epithelium, laryngeal papilloma and normal laryngeal epithelium. But 
      there was no statistically significant correlations between Survivin protein 
      expression and the clinicopathological characteristics of tumor site, T-stage, 
      pathological grading, UICC-stage and lymph node metastasis (P > 0.05). Expression 
      of Survivin protein in 3 cases in laryngeal papilloma group which turned into 
      laryngeal carcinoma later were all positive. CONCLUSION: There was overexpression 
      of Survivin in the laryngeal carcinoma. The expression of Survivin might play an 
      important role in the carcinogenesis of LSCC and might be an early event during 
      laryngeal carcinogenesis. It could be a diagnostic marker for evaluating the 
      malignant potential of laryngeal papilloma in adults.
FAU - Xie, Hong
AU  - Xie H
AD  - Department of Otorhinolaryngology, Shijitan Hospital, Beijing, 100038, China. 
      xiehong2008@sina.com
FAU - Zhang, Baoquan
AU  - Zhang B
FAU - Yin, Jinshu
AU  - Yin J
FAU - Song, Faquan
AU  - Song F
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Papilloma/*metabolism/pathology
MH  - Survivin
MH  - Young Adult
EDAT- 2007/07/20 09:00
MHDA- 2011/06/03 06:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 May;21(9):413-6.