PMID- 17634027
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20070719
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 21
IP  - 9
DP  - 2007 May
TI  - [Elemene in the treatment of the transplantable model of human laryngeal squamous 
      carcinoma in nude mice].
PG  - 417-20
AB  - OBJECTIVE: To investigate the inhibitory effect of elemene on the tumor growth of 
      human laryngeal squamous carcinoma (LSCC) and to explore the possible mechanism 
      of its inhibitory effect on LSCC. METHOD: Nude mice model engrafted with 
      laryngocarcinoma was established by using human laryngeal squamous carcinoma cell 
      line (Hep-2). When the transplantable tumor size is more than 10 mm, the mice 
      were given elemene (120 mg/kg) in the treatment group or PBS in the control 
      group, at the day of 1, 4, 7, 10, 13, 16, 19 and 22 respectively. The animals 
      were killed three days after the last treatment. The tumor volume, tumor 
      weight,mice net weight and tumor inhibition rate were measured. The expression of 
      vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth 
      factor receptor-3 (VEGFR-3) mRNA were quantitated by using reverse transcription 
      and polymerase chain reaction technique. RESULT: Elemene could inhibit the tumor 
      growth in vivo. The differences were statistically significant for the mice net 
      weight, tumor weight, and tumor volume between the treatment group and the 
      control group. The tumor inhibition percentage was 52.24%. The gene expression of 
      VEGF-C and VEGFR-3 of the treatment group is lower than that of the control group 
      and the differences were statistically significant (P < 0.01). CONCLUSION: 
      Elemene could inhibit the subcutaneous plantation of human laryngeal carcinoma in 
      nude mice and its mechanism may be associated with inhibited expression of VEGF-C 
      and VEGFR-3.
FAU - Cao, Zhongsheng
AU  - Cao Z
AD  - Department of Otorhinolaryngology, the First Affiliated Hospital of Dalian 
      Medical University, Dalian, 116011, China. cao4018@yahoo.com.cn
FAU - Ji, Wenyue
AU  - Ji W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Sesquiterpenes)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - 0 (vascular endothelial growth factor C, mouse)
RN  - 11029-06-4 (elemene)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-3)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Phytogenic/*therapeutic use
MH  - Carcinoma, Squamous Cell/*drug therapy
MH  - Cell Line, Tumor
MH  - Drugs, Chinese Herbal/therapeutic use
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - *Phytotherapy
MH  - Sesquiterpenes/*therapeutic use
MH  - Vascular Endothelial Growth Factor C/metabolism
MH  - Vascular Endothelial Growth Factor Receptor-3/metabolism
MH  - Xenograft Model Antitumor Assays
EDAT- 2007/07/20 09:00
MHDA- 2011/06/03 06:00
CRDT- 2007/07/20 09:00
PHST- 2007/07/20 09:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PHST- 2007/07/20 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 May;21(9):417-20.